Individual differences in during decision making under uncertainty: Loss aversion covaries with insular grey matter volume

Markett, Sebastian; Voigt, Gesine; Montag, Christian; Weber, Bernd; Reuter, Martin

doi:10.1016/j.paid.2013.07.183

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“…Besides processing current information about risk, individual preferences modulate the activity. Loss aversion, a tendency to overweight potential losses compared to gains, has been associated with gray matter volume reductions in the insula repeatedly [Markett et al, 2014[Markett et al, , 2016. In choice tasks, harm avoidance has been associated with elevated insular activity [Paulus et al, 2003;Votinov et al, 2010Votinov et al, , 2013 and risk preferences with blunted insula activity [Kuhnen and Knutson, 2005].…”

Section: The Influence Of Testosterone and Maoa Polymorphism On Decismentioning

confidence: 99%

Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism

et al. 2017

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Testosterone, a male sex hormone, has been suggested to partly explain mixed findings in males and females when investigating behavioral tendencies associated with the MAOA polymorphism. Prior studies indicated that the MAOA polymorphism represents a vulnerability factor for financial risk-taking and harm avoidance and that testosterone increases human risk-taking. We therefore assumed an interactive influence of the MAOA polymorphism and testosterone application on decision making and corresponding neural correlates in a risk and reward context. Stratified for the MAOA polymorphism (S =short, L =long), 103 healthy males were assigned to a placebo or testosterone group (double blind, randomized) receiving a topical gel containing 50 mg testosterone. During a functional MRI scan, the participants performed a sequential decision making task. Our results indicate that testosterone and the MAOA polymorphism jointly influence sequential decision making. The MAOA-S variant was associated with less automatic harm avoidance as reflected in response times on safe decisions. Moreover, after testosterone administration, MAOA-S carriers were more risk-taking. Overall activity in the anterior cingulate cortex, anterior insula and inferior frontal gyrus increased with growing risk for losses. In the anterior insula, testosterone administration mitigated this effect solely in MAOA-S carriers. This might be a reflection of an improved coping during risk-reward conflicts subsequently modulating risky decision making. While the molecular basis is not well defined so far, our results support the assumption of testosterone as a modulatory factor for previously reported sex differences of behavioral associations with the MAOA-S variant. Hum Brain Mapp 38:4574-4593, 2017. © 2017 Wiley Periodicals, Inc.

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Section: The Influence Of Testosterone and Maoa Polymorphism On Decismentioning

confidence: 99%

Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism

et al. 2017

View full text Add to dashboard Cite

show abstract

Individual differences in during decision making under uncertainty: Loss aversion covaries with insular grey matter volume

Cited by 1 publication

References 0 publications

Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism

Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism

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