Individual differences in local gray and white matter volumes reflect differences in temperament and character: A voxel-based morphometry study in healthy young females

Schuerbeek, Peter Van; Baeken, Chris; Raedt, Rudi De; Mey, Johan De; Luypaert, Robert

doi:10.1016/j.brainres.2010.11.073

Cited by 81 publications

(102 citation statements)

References 64 publications

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“…A recent diffusion tensor imaging (DTI) study (Cohen et al, 2009) reported that fiber connectivity between the striatum, hippocampus, and amygdala could predict individual differences in NS. Two brain anatomical studies also found that NS was correlated with white matter volume in the frontal cortex and gray matter volume in the frontal cortex and PCC (Gardini et al, 2009;Van Schuerbeek et al, 2011). Consistent with the structural data, functional brain studies reported that the striatum, substantia nigra and ventral tegmental regions (Krebs et al, 2009), and prefrontal cortical regions (Bermpohl et al, 2008) were involved in NS.…”

Section: Introductionsupporting

confidence: 53%

“…Cohen et al, 2009 found that fiber connectivity between the striatum and frontal cortex was associated with individual differences in RD. RD has also been correlated with gray matter volumes of the frontal and temporal regions and caudate nucleus (Gardini et al, 2009;Van Schuerbeek et al, 2011), and gray matter densities of the medial orbitofrontal cortex, ventral striatum, and putamen (Lebreton et al, 2009). Functional brain imaging studies confirmed the key role of the striatum and orbitofrontal cortex in RD and reward processing (Krebs et al, 2009).…”

Section: Introductionmentioning

confidence: 87%

“…In a separate study (Cohen et al, 2009), P was positively correlated with fiber connectivity from the mOFC to the striatum. P was also linked to gray and white matter volume of the cortices and limbic regions, such as the paracentral lobule, precuneus and cingulate gyrus (Gardini et al, 2009;Van Schuerbeek et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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Section: Introductionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 87%

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Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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“…Neuroimaging studies have examined the correlation between NS and cortical volume in several brain regions (Gardini et al, 2009;Iidaka et al, 2006;Schilling et al, 2013b;Van Schuerbeek et al, 2011), however, these findings are mixed. Some research found that NS was associated with cortical volume in the middle frontal gyrus (Iidaka et al, 2006) and orbitofrontal cortex (Schilling et al, 2013b), whereas some others found associations with regions such as the posterior cingulate regions (Gardini et al, 2009;Van Schuerbeek et al, 2011) and cerebellum (Van Schuerbeek et , 2011).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Some research found that NS was associated with cortical volume in the middle frontal gyrus (Iidaka et al, 2006) and orbitofrontal cortex (Schilling et al, 2013b), whereas some others found associations with regions such as the posterior cingulate regions (Gardini et al, 2009;Van Schuerbeek et al, 2011) and cerebellum (Van Schuerbeek et , 2011). These inconsistent results might be attributed to differences in sample size, methods, or statistical model specifications (Hu et al, 2011).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

Cui

et al. 2015

NeuroImage

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The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking, NeuroImage (2015), doi: 10.1016/j.neuroimage. 2015.05.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 AbstractNovelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship.Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure.

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Novelty seeking and reward dependence‐related large‐scale brain networks functional connectivity variation during salience expectancy

Demenescu

Sweeney‐Reed

et al. 2017

Human Brain Mapping

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A salience network (SN) anchored in the anterior insula (AI) and dorsal anterior cingulate cortex (dACC) plays a key role in switching between brain networks during salience detection and attention regulation. Previous fMRI studies have associated expectancy behaviors and SN activation with novelty seeking (NS) and reward dependence (RD) personality traits. To address the question of how functional connectivity (FC) in the SN is modulated by internal (expectancy-related) salience assignment and different personality traits, 68 healthy participants performed a salience expectancy task using functional magnetic resonance imaging, and psychophysiological interaction analysis (PPI) was conducted to determine salience-related connectivity changes during these anticipation periods. Correlation was then evaluated between PPI and personality traits, assessed using the temperament and character inventory of 32 male participants. During high salience expectancy, SN-seed regions showed reduced FC to visual areas and parts of the default mode network, but increased FC to the central executive network. With increasing NS, participants showed significantly increasing disconnection between right AI and middle cingulate cortex when expecting high-salience pictures as compared to low-salience pictures, while increased RD also predicted decreased right dACC and caudate FC for high salience expectancy. Our findings suggest a direct link between personality traits and internal salience processing mediated by differential network integration of the SN. SN activity and coordination may therefore be moderated by novelty seeking and reward dependency personality traits, which are associated with risk of addiction. Hum Brain Mapp 38:4064-4077, 2017. © 2017 Wiley Periodicals, Inc.

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Individual differences in local gray and white matter volumes reflect differences in temperament and character: A voxel-based morphometry study in healthy young females

Cited by 81 publications

References 64 publications

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

Novelty seeking and reward dependence‐related large‐scale brain networks functional connectivity variation during salience expectancy

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