Individual differences in locomotor activity and sensitization

Hooks, M.S.; Jones, G. H.; Smith, Amanda D.; Neill, Darryl B.; Justice, Joseph B.

doi:10.1016/0091-3057(91)90308-o

Cited by 186 publications

(141 citation statements)

References 13 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…We observed a negative correlation between locomotor response to saline injection and initial locomotor response to AMPH, in contrast to earlier reports of a positive correlation between heightened locomotor response to novelty and increased locomotor response to AMPH and cocaine in some (Piazza et al, 1989;Hooks et al, 1991Hooks et al, , 1992 but not all (Djano and Martin-Iverson, 2000) studies. Differences in experimental details (eg measurement of response to novelty vs our measure, response to saline injection in a novel environment) might account for the differing observations.…”

Section: Comparison With Previous Findingscontrasting

confidence: 99%

“…A relation between locomotor response to novelty and subsequent locomotor response to AMPH and cocaine has previously been described by several (Piazza et al, 1989;Hooks et al, 1991Hooks et al, , 1992, but not all investigators (Djano and Martin-Iverson, 2000). Because locomotor response to novelty might potentially influence locomotor response to saline injection, one of the measures contributing to our defined PD 128907 locomotor inhibition, the correlation between AMPH-stimulated locomotion, and responses to PD 128907 and saline (Table 3, days 12-14) were also evaluated individually.…”

Section: Behavioral Response To Amphetamine and To D3 Receptor Agonismentioning

confidence: 98%

See 1 more Smart Citation

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Richtand

Welge

Levant

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

Behavioral sensitization, the progressive and enduring enhancement of certain behaviors following repetitive drug use, is mediated in part by dopaminergic pathways. Increased locomotor response to drug treatment, a sensitizable behavior, is modulated by an opposing balance of dopamine receptor subtypes, with D1/D2 dopamine receptor stimulation increasing and D3 dopamine receptor activation inhibiting amphetamine-induced locomotion. We hypothesize that tolerance of D3 receptor locomotor inhibition contributes to behavioral sensitization. In order to test the hypothesis that expression of behavioral sensitization results in part from release of D3 receptor-mediated inhibition, thereby resulting in decreased response to D3 receptor agonists, we examined the effect of repetitive amphetamine administration on the behavioral response to the D3 receptor preferring agonists 7-OH-DPAT and PD 128907. D3-selective effects have recently been described for both drugs at a low dose. At 1 week following completion of a repetitive treatment regimen, amphetamine-pretreated rats displayed a decreased response to D3-selective doses of both 7-OH-DPAT and PD 128907, when compared to animals receiving saline pretreatment. Moreover, in addition to the quantitative alteration in response, there was a change in the inter-relation between response to amphetamine and D3 agonist. A highly significant inverse relation between locomotor inhibitory response to PD 128907 and the locomotor-stimulant response to amphetamine was observed prior to amphetamine treatment. In contrast, 10 days following repetitive amphetamine treatment, the relation between response to PD 128907 and amphetamine was not detected. The observed behavioral alteration could not be accounted for by changes in D3 receptor binding in ventral striatum. These findings suggest a persistent release of D3 receptor-mediated inhibitory influence contributes to the expression of behavioral sensitization to amphetamine.

show abstract

Section: Comparison With Previous Findingscontrasting

confidence: 99%

Section: Behavioral Response To Amphetamine and To D3 Receptor Agonismentioning

confidence: 98%

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Richtand

Welge

Levant

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…For example, rats with high novelty-induced locomotor activity (high responders, HR) acquired i.v. amphetamine (Hooks et al, 1991a;Piazza et al, 1989Piazza et al, , 1990 and cocaine (Hooks et al 1991b;Mantsch et al, 2001;Piazza et al, 1998) self-administration more readily than low responders (LR), showing a potential connection between intake of sweetened substances and drugs, the HR rats also consumed greater amounts of sucrose than LR rats (Cools and Gingras, 1998). The elevated response to novelty and corresponding vulnerability to drug self-administration in rats has been suggested to be analogous to high sensation-seeking behaviors in humans (Dellu et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake

Carroll

Anderson

Morgan

2007

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Rats selectively bred for high saccharin consumption (HiS) self-administer more oral ethanol and i.v. cocaine than those selectively bred for low saccharin consumption (LoS). Male and female drug-seeking-prone (HiS) and -resistant (LoS) rats were used in the present experiment to test the prediction that cocaine-induced locomotor activity and sensitization varied with sex and their selective breeding status (HiS and LoS). All rats were intermittently exposed over 2 weeks to pairs of sequential saline and cocaine injections, separated by 45 min. The first 5 pairs of injections, each separated by 2-3 days (10-12 days total), were given to examine the development of cocaineinduced locomotor activity and the development of locomotor sensitization, which was determined by comparing the effects of cocaine injection 1 with injection 6, which was given 2 weeks after the 5 pairs of intermittent injections. Results indicated that after the first injection pair (saline, cocaine) the HiS and LoS groups did not differ (saline vs. cocaine) in locomotor activity; however, after cocaine injections 1, 5 and 6, HiS females were more active than HiS males and LoS females. There were also significant phenotype differences (HiS > LoS) in locomotor activity after cocaine injections 5 and 6. There was only a weak sensitization effect in cocaine-induced locomotor activity in HiS females after cocaine injection 5 (compared to 1); however it was not present after injection 6 or in other groups. The lack of a strong sensitization effect under these temporal and dose conditions was inconsistent with previous reports. However, the results showing HiS > LoS and females > males on cocaine-induced activity measures are consistent with several measures of cocaine-seeking behavior (acquisition, maintenance, escalation, extinction, and reinstatement), and they suggest that cocaine-induced locomotor activity and sensitization are behavioral markers of drug-seeking phenotypes.

show abstract

“…These individual differences have been observed both in outbred and inbred strains of mice (Ruth et al, 1988;George and Ritz, 1990;Henricks et al, 1997;Marley et al, 1998;Rocha et al, 1998). Likewise, variability in COC-induced behaviors has been observed in rats, predominantly in the propensity of rats, often initially classified as either low or high responders to novelty, to self-administer drug (Glick et al, 1994;Piazza et al, 2000), or to become behaviorally sensitized (Hooks et al, 1991a;Hooks et al, 1992;Djano and Martin-Iverson, 2000;Chefer et al, 2003). Differences in initial responsiveness of humans to cocaine also reflect both genetic and environmental influences and are one factor that determines whether or not an individual will become addicted to cocaine (Haertzen et al, 1983;Davidson et al, 1993).…”

Section: Introductionmentioning

confidence: 97%

Individual Differences in Cocaine- and Amphetamine-Induced Activation of Male Sprague–Dawley Rats: Contribution of the Dopamine Transporter

Briegleb

Gulley

Hoover

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

Previously we found that outbred male Sprague-Dawley rats can be classified as either low or high cocaine responders (LCRs or HCRs, respectively), based on their open-field locomotor response to acute cocaine (COC; 10 mg/kg, i.p.). Here, we extended this analysis to amphetamine (AMPH; 0.5, 1, and 5 mg/kg, i.p.) and found that the individual differences in behavioral activation were not as pronounced as with COC. This was confirmed with observational analysis of behaviors. Differences in drug-induced activation could involve differential dopamine transporter (DAT) function/trafficking. To address this possibility, we measured [ 3 H]DA uptake into dorsal striatal synaptosomes prepared from rats injected 30 min earlier with saline, COC, or AMPH to determine DAT activity, and radioligand binding to determine the total number of DATs. Striatal [ 3 H]DA uptake in COC-treated HCRs was significantly higher than in LCRs. Furthermore, regardless of LCR/HCR classification, uptake in individual COC-treated rats was significantly correlated with their locomotor behavior in the 30 min after drug administration. In contrast, AMPH-treated rats did not differ in uptake, nor were uptake and locomotor activity correlated. DAT number did not differ between LCRs or HCRs, or between AMPH-treated rats. In addition, when individual differences in COC-induced behavior were no longer detected in LCRs and HCRs 1 week after initial classification, uptake was also similar. Together, these results suggest that a difference in expression of functional DATs on the cell surface contributes to the individual differences observed in COC-induced, but not AMPH-induced, behavioral activation of rats.

show abstract

Individual differences in locomotor activity and sensitization

Cited by 186 publications

References 13 publications

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake

Individual Differences in Cocaine- and Amphetamine-Induced Activation of Male Sprague–Dawley Rats: Contribution of the Dopamine Transporter

Contact Info

Product

Resources

About