Individual differences in <scp>EEG</scp> correlates of recognition memory due to <scp>DAT</scp> polymorphisms

Medrano, Paolo; Nyhus, Erika; Smolen, Andrew; Curran, Tim; Ross, Robert S.

doi:10.1002/brb3.870

Cited by 10 publications

(7 citation statements)

References 94 publications

(174 reference statements)

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“…We propose that LPC amplitude measures using stimulus-locked ERPs are susceptible to sources of variance (and potentially bias) depending on the RT distributions for hits and correct rejections. For example, if RTs are faster for hits compared to correct rejections, as observed in behavioural (Ratcliff & Murdock, 1976; Wilding et al, 1996) and EEG studies (Glaser et al, 2012; Medrano et al, 2017; Rubin et al, 1999; Yu et al, 2022) as well as our own data, the LPC will peak earlier relative to stimulus onset for hits. This would produce apparent stimulus-locked amplitude differences that are partly due to shifts in ERP component latency (rather than amplitude).…”

Section: Discussionsupporting

confidence: 63%

The Late Positive Event-Related Potential Component is Time-Locked to the Decision in Recognition Memory Tasks

Sun,

Osth,

Feuerriegel

2023

Preprint

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Two event-related potential (ERP) components are commonly observed in recognition memory tasks: the Frontal Negativity (FN400) and the Late Positive Component (LPC). These components are widely interpreted as neural correlates of familiarity and recollection, respectively. However, the interpretation of LPC effects is complicated by inconsistent results regarding the timing of ERP amplitude differences. There are also mixed findings regarding how LPC amplitudes covary with decision confidence. Critically, LPC effects have almost always been measured using fixed time windows relative to memory probe stimulus onset, yet it has not been determined whether LPC effects are time-locked to the stimulus or the recognition memory decision. To investigate this, we analysed a large (n=l32) existing dataset recorded during recognition memory tasks with post-decisional confidence ratings. We used ERP deconvolution to disentangle contributions to LPC effects (defined as differences between hits and correct rejections) that were time-locked to either the stimulus or the vocal old/new response. We identified a left-lateralised parietal LPC effect that was time-locked to the vocal response rather than probe stimulus onset. We also isolated a response-locked, midline parietal ERP correlate of confidence that influenced measures of LPC amplitudes at left parietal electrodes. Our findings demonstrate that, contrary to widespread assumptions, the LPC effect is time-locked to the recognition memory decision and is best measured using response-locked ERPs. By extension, differences in response time distributions across conditions of interest may lead to substantial measurement biases when analysing stimulus-locked ERPs. Our findings highlight important confounding factors that further complicate the interpretation of existing stimulus-locked LPC effects as neural correlates of recollection. We recommend that future studies adopt our analytic approach to better isolate LPC effects and their sensitivity to manipulations in recognition memory tasks.

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Section: Discussionsupporting

confidence: 63%

The Late Positive Event-Related Potential Component is Time-Locked to the Decision in Recognition Memory Tasks

Sun,

Osth,

Feuerriegel

2023

Preprint

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“…Spatiotemporal regions of interest (ROIs) were defined according to previous research showing event-related potential (ERP) and theta oscillatory effects during source memory retrieval (Nyhus and Badre, 2015; Ross et al, 2015, 2018; Medrano et al, 2017). The ROIs were left parietal and right frontal channel groups (see Figures 2C, 3C, 4C); mean theta (4–8 Hz) power from 1000 to 1500 ms was computed by averaging the channels within each region for each condition/subject.…”

Section: Resultsmentioning

confidence: 99%

Increases in Theta Oscillatory Activity During Episodic Memory Retrieval Following Mindfulness Meditation Training

Nyhus

Engel

Pitfield

et al. 2019

Front. Hum. Neurosci.

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Mindfulness meditation has been shown to improve episodic memory and increase theta oscillations which are known to play a role in episodic memory retrieval. The present study examined the effect of mindfulness meditation on episodic memory retrieval and theta oscillations. Using a longitudinal design, subjects in the mindfulness meditation experimental group who underwent 4 weeks of mindfulness meditation training and practice were compared to a waitlist control group. During the pre-training and post-training experimental sessions, subjects completed the Five Facet Mindfulness Questionnaire (FFMQ) and studied adjectives and either imagined a scene (Place Task) or judged its pleasantness (Pleasant Task). During the recognition test, subjects decided which task was performed with each word (“Old Place Task” or “Old Pleasant Task”) or “New.” FFMQ scores and source discrimination were greater post-training than pre-training in the mindfulness meditation experimental group. Electroencephalography (EEG) results revealed that for the mindfulness meditation experimental group theta power was greater post-training than pre-training in right frontal and left parietal channels and changes in FFMQ scores correlated with changes in theta oscillations in right frontal channels (n = 20). The present results suggest that mindfulness meditation increases source memory retrieval and theta oscillations in a fronto-parietal network.

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“…Participants for the study were recruited from the University of Colorado Boulder community. Data from these same participants examining how the 5HTTLPR serotonin transporter polymorphism affects ERP’s and how dopamine transporter polymorphisms affect ERP’s and oscillatory power during recognition memory has been reported elsewhere (Ross et al, 2015 ; Medrano et al, 2017 ). Participants were given monetary compensation for their participation.…”

Section: Methodsmentioning

confidence: 97%

MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Ross

Smolen

Curran

et al. 2018

Front. Hum. Neurosci.

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A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of the MAO-A gene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted by MAO-A phenotype during item and source memory. Our results show that individuals with the MAO-A phenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new effect is not present due to increased ERP amplitude for correct rejections. The results suggest that MAO-A phenotype changes EEG correlates of recognition memory and influences how well individuals differentiate between old and new items.

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Individual differences in EEG correlates of recognition memory due to DAT polymorphisms

Cited by 10 publications

References 94 publications

The Late Positive Event-Related Potential Component is Time-Locked to the Decision in Recognition Memory Tasks

The Late Positive Event-Related Potential Component is Time-Locked to the Decision in Recognition Memory Tasks

Increases in Theta Oscillatory Activity During Episodic Memory Retrieval Following Mindfulness Meditation Training

MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

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