Abstract:Drug discrimination has been a useful behavioral approach for understanding the neuropharmacological mechanisms of drug‐induced stimuli. Naltrexone (NTX) is an opioid antagonist with known binding affinities for mu‐, kappa‐, and delta‐opioid receptors. Our present study investigates the receptor‐mediated discriminative stimulus effects of NTX, as well as differences in stimulus control maintenance. We previously reported that rats given chronic, intermittent sucrose access can be trained to discriminate NTX (0… Show more
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