Individual Differences in Volitional Social Self-Administration and Motivation in Male and Female Mice Following Social Stress

Navarrete, Jovana; Schneider, Kevin N.; Smith, Briana M.; Goodwin, Nastacia L.; Zhang, Yizhe Y.; Salazar, Axelle S.; Gonzalez, Yahir E.; Anumolu, Pranav; Gross, Ethan; Tsai, Valerie S.; Heshmati, Mitra; Golden, Sam A.

doi:10.1016/j.biopsych.2024.01.007

Cited by 2 publications

(1 citation statement)

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“…A recent study using mice's operant social stress paradigm revealed that males and females use different stress-coping behavioral strategies. While males exhibit social avoidance, females pursue social interaction (Navarrete, Schneider et al 2024), which can be explained by stress-induced social arousal and is consistent with our finding of elevated fear synchrony in stressed females. Moreover, the lack of stressinduced synchrony loss, as seen in males, can result from the protective effects of estrogen in females, which dampens the dmPFC response to stress (Wei, Yuen et al 2014, Velli, Iordanidou et al 2022.…”

Section: Discussionsupporting

confidence: 92%

Sex and stress interactions in fear synchrony of mouse dyads

Ito,

Morozov

2024

Preprint

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Socially coordinated threat responses support the survival of animal groups. Given their distinct social roles, males and females must differ in such coordination. Here, we report such differences during the synchronization of auditory-conditioned freezing in mouse dyads. To study the interaction of emotional states with social cues underlying synchronization, we modulated emotional states with prior stress or modified the social cues by pairing unfamiliar or opposite-sex mice. In same-sex dyads, males exhibited more robust synchrony than females. Stress disrupted male synchrony in a prefrontal cortex-dependent manner but enhanced it in females. Unfamiliarity moderately reduced synchrony in males but not in females. In dyads with opposite-sex partners, fear synchrony was resilient to both stress and unfamiliarity. Decomposing the synchronization process in the same-sex dyads revealed sex-specific behavioral strategies correlated with synchrony magnitude: following partners’ state transitions in males and retroacting synchrony-breaking actions in females. Those were altered by stress and unfamiliarity. The opposite-sex dyads exhibited no synchrony-correlated strategy. These findings reveal sex-specific adaptations of socio-emotional integration defining coordinated behavior and suggest that sex-recognition circuits confer resilience to stress and unfamiliarity in opposite-sex dyads.

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Section: Discussionsupporting

confidence: 92%