To describe the 5 years' trajectories in functionality and pain of patients with hip or knee osteoarthritis and arthroplasty and analyze the association of these with long-term patients survival. Patients with oA receiving total hip or knee arthroplasty were recruited and completed two sets of standardized questionnaires for functionality and pain 6, 12, and 60 months postoperatively. Multivariate mixed models were conducted to assess trajectories over time and the resulting improvement per month during the last time period was included in a landmark-model to estimate adjusted hazard ratios for mortality. In total 809 patients with joint replacement were included (mean age 65.0 years, 62.2% female), 407 patients died (median follow-up 18.4 years). Both instruments of functionality and pain showed extensive improvement during the first 6 months. Baseline and change in functionality (both p < 0.001) and pain (p = 0.02) during the first 6 months were associated with mortality. Better values in functionality corresponded with improved survival whereas the association with the pain scores was inverse. In patients with hip and knee OA, an explicit improvement in function is seen within the first 6 months after arthroplasty. In addition, especially the functionality scores at baseline as well as their improvement showed an association with long-term patient survival. Osteoarthritis (OA) is a very common musculoskeletal disorder. Prevalence of OA is increasing with age and OA leads to functional disability and pain in the joints 1,2. Arthroplasty is an established treatment in symptomatic patients in order to restore functionality, relief pain, and increase overall quality of life. It prevents disability and also enables a renewed physically active lifestyle, which is an important component of health 3. Overall, patients with OA seem to have no increased all-cause mortality compared to the general population, also previous studies revealed inconsistent results 4. A recent meta-analysis which investigated the association of symptomatic or radiological OA and all-cause mortality came to the conclusion that so far no reliable evidence exists for an association of OA with general and all-cause mortality 5. We came to a similar conclusion when analyzing the 20 years' mortality after the first hip or knee joint replacement in our study population 6. However, as impaired function and chronic pain associated with OA may result in disability as well as in decreased physical activity, these patients may also have long-term consequences on a variety of health-related endpoints, and