Individual plasma ghrelin changes in the same patients in hyperthyroid, hypothyroid and euthyroid state

Ruchała, Marek; Gurgul, Edyta; Stangierski, Adam; Wrotkowska, Elżbieta; Moczko, Jerzy

doi:10.1016/j.peptides.2013.10.018

Cited by 14 publications

(16 citation statements)

References 39 publications

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“…All patients were asked to refrain from smoking and drinking tea or coffee for at least 12 hours, and from drinking any alcohol for at least 24 hours before blood sampling. The concentrations of TSH, fT3, and fT4 were assessed with the use of the (1) between the concentrations of fT3, fT4, and TSH with components of body mass for pooled data (total n = 135 -3 visits times 45 patients); and (2) between the changes in hormone concentrations and body composition measured between Visit 1 and 2 (n = 45), and Visit 2 and 3 (another n = 45) for pooled data (total n = 90); p < 0.05 was considered statistically significant. Statistical analyses were made with the use of Medcalc softwere (version 13.0.4.0) (Medcalc, Belgium).…”

Section: Biochemical Analysismentioning

confidence: 99%

“…Thyroid hormones regulate the metabolism of the whole human body -triiodothyronine (T3) is necessary to maintain the energy requirements of various cells and tissues, to balance their anabolism and catabolism, and regulate body weight [1][2][3][4]. An abnormal amount of T3 disturbs a number of metabolic processes [2]: shortage of T3 in hypothyroidism reduces basic metabolic rate and thermogenesis, inhibits catabolism and gains total body weight [5]; excess of T3 in hyperthyroidism reverses these processes [6].…”

Section: Introductionmentioning

confidence: 99%

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Zmiany w składzie tkankowym obserwowane w trakcie terapii ciężkich zaburzeń funkcji tarczycy

Stangierski

Ruchała

Krauze

et al. 2015

Endokrynologia Polska

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Introduction: Hyper-and hypothyroidism are accompanied by altered metabolic rate, thermogenesis, and body weight. The aim of this study was to estimate the relation between treatment-induced changes in thyroid function, and the accompanying body composition in patients with either severe hypo-or hyperthyroidism. Material and methods: Body composition analysis and hormonal assessment were measured at the initial diagnosis of thyroid disorder, after three-month treatment, and finally after complete recovery from hyperthyroidism (n = 18) or hypothyroidism (n = 27). Nonparametric Spearman correlation was used to analyse the relation between thyroid hormones and body composition as well as their respective changes. Results:In hypothyroid patients applied treatment significantly reduced (p < 0.05) total body weight, mainly due to a decrease in fat mass, whereas in hyperthyroid patients it caused a weight gain, with a simultaneous increase in muscle, water and fat mass. Total body weight and fat mass were significantly correlated with thyroid hormones' concentrations in all patients. Changes of fat, water, or muscle mass were strongly correlated with the changes in the patients' hormonal status.

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Section: Biochemical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zmiany w składzie tkankowym obserwowane w trakcie terapii ciężkich zaburzeń funkcji tarczycy

Stangierski

Ruchała

Krauze

et al. 2015

Endokrynologia Polska

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“…The thyroid gland of the crested porcupine (Hystrixcristata) has also been described to exhibit irisin immunoreactivity . As other metabolically active novel peptides, such as ghrelin, obestatin or visfatin, are influenced by thyroid hormones levels, this influence on irisin concentration has become an interesting focus of research. The influence of different pathologies on FNDC5 expression in thyroid tissue and its possible influence on changes in irisin concentration have not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

The association between irisin and muscle metabolism in different thyroid disorders

Zybek-Kocik

Sawicka‐Gutaj

Szczepanek‐Parulska

et al. 2017

Clinical Endocrinology

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“…The relationship between thyroid cancer pathogenesis and ghrelin and obestatin expression has not been clearly defined. Furthermore, since the function of thyroid gland is associated with the maintenance of energy balance, the relationship between ghrelin, obestatin and thyroid function is worthy of consideration [19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Ghrelin and obestatin in thyroid gland — immunohistochemical expression in nodular goiter, papillary and medullary cancer

Gurgul

Kasprzak

Błaszczyk

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Previous studies analyzing ghrelin and obestatin expression in thyroid gland tissue are not unanimous and are mostly related to ghrelin. The role of ghrelin and obestatin in the thyroid gland appears very interesting due to their probable involvement in cell proliferation. Furthermore, since the thyroid gland is associated with the maintenance of energy balance, the relationship between ghrelin, obestatin and thyroid function is worthy of consideration. The aim of the study was to assess ghrelin and obestatin immunocytochemical expression in nodular goiter (NG), papillary cancer (PTC) and medullary cancer (MTC). Material and methods. Analyzed samples included 9 cases of NG, 8 cases of PTC and 11 cases of MTC. The analysis of ghrelin and obestatin expression was performed by use of the immunohistochemical (IHC) EnVision system and evaluated with filter HSV software (quantitative morphometric analysis). Results. Quantitative ghrelin expression in MTC cells was higher than in NG (p = 0.013) and correlated negatively with the size of the tumor (r= -0.829, p < 0.05). We did not observe any differences in ghrelin expression neither between MTC and PTC nor between NG and PTC. Obestatin immunoexpression pattern in all analyzed specimens was irregular and poorly accented. The strongest immunoreactivity for obestatin was demonstrated in NG. In MTC obestatin expression was significantly weaker than in NG and PTC (p < 0.05 in both cases). In NG the intensity of obestatin immunostaining was significantly higher than that of ghrelin (p = 0.03). Conversely, ghrelin expression in MTC was definitely more evident than obestatin immunoreactivity (p < 0.01). There was no statistically significant difference between ghrelin and obestatin expression in PTC. No correlations were detected between reciprocal tissue expressions of ghrelin and obestatin in the analyzed specimens of NG, PTC or MTC. Conclusions. The differences between ghrelin expression in NG and MTC suggest that ghrelin may be involved in thyroid cell proliferation. The differences between ghrelin and obestatin immunoreactivity in benign and malignant thyroid tumors could support the theory of alternative transcription of the preproghrelin gene and independent production of ghrelin and obestatin.

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Individual plasma ghrelin changes in the same patients in hyperthyroid, hypothyroid and euthyroid state

Cited by 14 publications

References 39 publications

Zmiany w składzie tkankowym obserwowane w trakcie terapii ciężkich zaburzeń funkcji tarczycy

Zmiany w składzie tkankowym obserwowane w trakcie terapii ciężkich zaburzeń funkcji tarczycy

The association between irisin and muscle metabolism in different thyroid disorders

Ghrelin and obestatin in thyroid gland — immunohistochemical expression in nodular goiter, papillary and medullary cancer

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