Abstract:BACKGROUND: Despite its importance in the clinical management of ovarian cancer, the CA125 biomarker, located on the mucin protein MUC16, is still not completely understood. Questions remain about MUC16 function and structure, specifically the identity and location of the CA125 epitopes. OBJECTIVE: The goal of this study was to characterize the interaction of individual recombinant repeats from the tandem repeat domain of MUC16 with antibodies used in the clinical CA125 II test. METHODS: Using E. coli expressi… Show more
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