Individual Sensitivity of the Peripheral Blood Lymphocytes to the in Vitro Action of Mitomycin C in Children with Juvenile Rheumatoid Arthritis

Abstract

The study was designed to estimate the levels of spontaneous and induced chromosome aberrations in the peripheral blood lymphocytes (PBL) of patients with juvenile rheumatoid arthritis (JRA) and their healthy peers. An increased spontaneous level of chromosomal aberrations has been found in children and adolescents with JRA in comparison with healthy agemates. It has been established that the effect of the mitomycin C model mutagen on the PBL in vitro causes a multiple increase in the levels of chromosomal aberrations in both groups under investigation.