Individual-specific multi-scale finite element simulation of cortical bone of human proximal femur

Ascenzi, Maria-Grazia; Kawas, Neal P.; Lutz, André; Kardas, Dieter; Nackenhorst, Udo; Keyak, Joyce H.

doi:10.1016/j.jcp.2012.05.027

Cited by 26 publications

(23 citation statements)

References 69 publications

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“…Also, the effect of HFD on MUT’s collagen orientation, now quantified in the cortical component of the whole shaft, confirms that the HFD alters the orientation of collagen in the MUT (Sage et al, 2011). Over the last fifty years, the experimental findings on the orientation of collagen type I have given rise to models of orientation patterns, that were incorporated in models to analyze the effect of such orientation (for reviews, Ascenzi et al, 1999, 2008 and 2013). Interestingly, we found that the distribution of collagen orientation does not differ between upper and lower shaft of murine femur.…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia affects multiscale structure and strength of murine femur

Ascenzi

Lutz

et al. 2014

Journal of Biomechanics

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To improve bone strength prediction beyond limitations of assessment founded solely on the bone mineral component, we investigated the effect of hyperlipidemia, present in more than 40% of osteoporotic patients, on multiscale structure of murine bone. Our overarching purpose is to estimate bone strength accurately, to facilitate mitigating fracture morbidity and mortality in patients. Because i) orientation of collagen type I affects, independently of degree of mineralization, cortical bone’s micro-structural strength; and, ii) hyperlipidemia affects collagen orientation and µCT volumetric tissue mineral density (vTMD) in murine cortical bone, we have constructed the first multiscale finite element (mFE), mouse-specific femoral model to study the effect of collagen orientation and vTMD on strength in Ldlr−/−, a mouse model of hyperlipidemia, and its control wild type, on either high fat diet or normal diet. Each µCT scan-based mFE model included either element-specific elastic orthotropic properties calculated from collagen orientation and vTMD (collagen-density model) by experimentally validated formulation, or usual element-specific elastic isotropic material properties dependent on vTMD-only (density-only model). We found that collagen orientation, assessed by circularly polarized light and confocal microscopies, and vTMD, differed among groups; and that microindentation results strongly correlate with elastic modulus of collagen-density models (r2=0.85, p=10−5). Collagen-density models yielded 1) larger strains, and therefore lower strength, in simulations of 3-point bending and physiological loading; and 2) higher correlation between mFE-predicted strength and 3-point bending experimental strength, than density-only models. This novel method supports ongoing translational research to achieve the as yet elusive goal of accurate bone strength prediction.

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Section: Discussionmentioning

confidence: 99%

Hyperlipidemia affects multiscale structure and strength of murine femur

Ascenzi

Lutz

et al. 2014

Journal of Biomechanics

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“…With time and growth, bones need to reshape and remodel by forming new osteons over that primary tissue (that continues with the lamellar structure) that is called interstitial tissue. Some authors affirm that interstitial tissue is more mineralized because minerals continue growing after remodeling (Martínez-Reina et al [2010]; Ascenzi et al [2013]; Prendergast and Huiskes [1996]). That theory is reasonable from the point of view of the protecting role that more fragility can give to interstitial bone over osteons (Schaffler et al [1995]).…”

Section: Elastic Properties Of Interstitial Tissuementioning

confidence: 99%

“…[1996] 6 GPa 0.25 Ascenzi et al [2013] 3.29 GPa 0.3 Li et al [2013] (2013) 9.64 GPa 0.3 Nobakhti et al [2014] 88.5 ± 22.42 MPa 0.3…”

Section: Elastic Properties Of Cement Linementioning

confidence: 99%

“…In previous chapters we have seen relevant models from bibliography (Ascenzi et al [2013]; Li et al [2013]; Nobakhti et al [2014]; Aoubiza et al [1996] among others) that have approached to cortical bone modeling at cortical microstructural level where model simplifications as geometry and constitutive properties are evident. Therefore, from validated damage models of previous chapters and publications ; Vercher-Martínez et al [2015]; ), we proceed to the implementation of a three-dimensional model where damage propagation can be analyzed, something that can be practically unapproachable with other methods such as the X-FEM or node-release technique due to the unaffordable computational cost and time required in setting up the model Giner et al [2009].…”

Section: Realistic Geometry Based On Micrographsmentioning

confidence: 99%

“…Bone failure and damage background More recent works as the proposed by Ascenzi et al [2013] analyse the mechanical behavior of bone with a complete three-dimensional multiscale model with patientspecific material properties presented with experimental validation at each structural level (micro-macro), where mechanical response is predicted in order to analyze strains under physiological loading conditions for long bones. In Fig.…”

Section: Introduction To Fem In Bone Analysismentioning

confidence: 99%

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Study of the mechanical behavior of cortical bone microstructure by the finite element method

Villegas¹

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Cortical bone tissue is the responsible of giving support and structure to vertebrates. For that reason, understanding and analyzing its behavior is needed from each different hierarchical level that composes it. The lower the structural scale is, the greater the complexity and scarcity of studies in literature. These studies are relevant for understanding, preventing and solving important health problems that affect human beings.From a mechanical point of view is interesting to evaluate and apply engineering numerical tools to analyze complex materials as biological tissues, increasing the state of the art in different disciplines that can be applied in numerous fields as material science, biomechanics, numerical methods, medicine and more.In this Thesis the mechanical behavior of cortical bone at microstructural level is analyzed, with finite element models of its basic structure, the osteon. The microstructure of osteons, composed of mineralized collagen fibrils in layers with different orientations disposed concentrically around blood vessels is considered in the models for the calculation of elastic properties and failure criteria definition.For obtaining elastic properties, the use of micromechanical finite element models is considered, with heterogeneous composition for both mineralized col-I lagen fibrils (at nanostructural level) and lamellar level (at sub-microstructural level).The failure analysis for realistic geometries is applied after comparing different models that involve, on one hand the growth of microcracks with contact conditions and on the other, degradation of elastic material properties by user subroutines of the finite element code, the latter being the one that brings better results from a computational cost viewpoint. Therefore an interesting alternative is here presented that can be used to evaluate the damage propagation at three-dimensional level, which with other methods as X-FEM can be computationally unaffordable.Composite materials failure criteria are applied to osteon analysis and the results are related with experimental tests from bibliography, showing the relevance of shear stresses between lamellae for failure initiation and propagation. In a two-dimensional study it is also shown the important role of osteocyte lacunae in the failure initiation, what is interesting from a cellular mechanotransduction approach. II C. Arango Villegas ResumenEl tejidoóseo cortical es el encargado de dar soporte y estructura a los vertebrados. Existe por tanto una necesidad de conocer y analizar mecánicamente su comportamiento desde los distintos niveles jerárquicos que lo componen, siendo mayor la complejidad y más escasos los estudios disponibles en la literatura cuanto más pequeña es la escala estructural que se analiza. Estos estudios son relevantes para comprender, prevenir y solucionar problemas de salud importantes que afectan al ser humano.Desde el punto de vista mecánico es interesante evaluar y aplicar herramientas numéricas ingenieriles para el análisis de materiales más co...

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