Individual treatment expectations predict clinical outcome after lumbar injections against low back pain

Müller-Schrader, Matthias; Heinzle, Jakob; Müller, Alfred; Lanz, Christian; Häussler, Oliver; Sutter, Martin; Eggspühler, Andreas; Mare, Stefania; Toussaint, Birte; Pereira, Inês; Petzschner, Frederike H.; Wiech, Katja; Barth, Jürgen; Witt, Claudia M.; Stephan, Klaas Ε.; Manjaly, Zina‐Mary

doi:10.1097/j.pain.0000000000002674

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…Although the ETS has shown to be a valid and reliable scale for measuring outcome expectations, it was originally developed in the context of acupuncture (Barth et al, 2019). While the scale has been used to determine outcome expectations across a variety of studies, there has been mixed evidence as to whether expectations predict therapeutic outcomes (de Matos et al, 2020;Barth et al, 2021;Egli et al, 2022;Zieger et al, 2022;Müller-Schrader et al, 2023). Further research should therefore be conducted using different treatment outcomes and patient populations to further explore to what extent the original scale and any modified versions are indeed able to accurately predict outcome expectations.…”

Section: Discussionmentioning

confidence: 99%

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

Siewert,

Teut,

Brinkhaus

et al. 2024

Front. Psychol.

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BackgroundThere is evidence that patients’ positive outcome expectations prior to study interventions are associated with better treatment outcomes. Nevertheless, to date, only few studies have investigated whether individual outcome expectations affect treatment outcomes in hypnosis.ObjectiveTo examine whether outcome expectations to hypnosis prior to starting treatment were able to predict perceived stress, as measured on a visual analog scale (VAS), after 5 weeks.MethodsWe performed a secondary data analysis of a multicenter randomized controlled trial of intervention group participants only. Study participants with stress symptoms were randomized to 5 weekly sessions of a group hypnosis program for stress reduction and improved stress coping, plus 5 hypnosis audio recordings for further individual practice at home, as well as an educational booklet on coping with stress. Perceived stress for the following week was measured at baseline and after 5 weeks using a visual analog scale (0–100 mm; VAS). Hypnosis outcome expectations were assessed at baseline only with the Expectations for Treatment Scale (ETS). Unadjusted and adjusted linear regressions were performed to examine the association between baseline expectations and perceived stress at 5 weeks.ResultsData from 47 participants (M = 45.02, SD = 13.40 years; 85.1% female) were analyzed. Unadjusted (B = 0.326, t = 0.239, p = 0.812, R2 = 0.001) and adjusted (B = 0.639, t = 0.470, p = 0.641, R2 = 0.168) linear regressions found that outcome expectations to hypnosis were not associated with a change in perceived stress between baseline and after 5 weeks in the intervention group.ConclusionOur findings suggest that the beneficial effect of group hypnosis in distressed participants were not associated with outcome expectations. Other mechanisms of action may be more important for the effect of hypnosis, which should be explored in future research.Clinical trial registration: ClinicalTrials.gov, identifier NCT03525093.

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Section: Discussionmentioning

confidence: 99%

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

Siewert,

Teut,

Brinkhaus

et al. 2024

Front. Psychol.

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“…RenderX [133,134], where expectations about pain treatment are reliable predictors of treatment response [135]. These studies suggest that an ongoing cognitive modulation of pain is an important determinant of ongoing pain perception [136].…”

Section: Xsl • Fomentioning

confidence: 91%

SOMAScience: A Novel Platform for Multidimensional, Longitudinal Pain Assessment

Gunsilius,

Heffner,

Bruinsma

et al. 2024

JMIR Mhealth Uhealth

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Chronic pain is one of the most significant health issues in the United States, affecting more than 20% of the population. Despite its contribution to the increasing health crisis, reliable predictors of disease development, progression, or treatment outcomes are lacking. Self-report remains the most effective way to assess pain, but measures are often acquired in sparse settings over short time windows, limiting their predictive ability. In this paper, we present a new mobile health platform called SOMAScience. SOMAScience serves as an easy-to-use research tool for scientists and clinicians, enabling the collection of large-scale pain datasets in single- and multicenter studies by facilitating the acquisition, transfer, and analysis of longitudinal, multidimensional, self-report pain data. Data acquisition for SOMAScience is done through a user-friendly smartphone app, SOMA, that uses experience sampling methodology to capture momentary and daily assessments of pain intensity, unpleasantness, interference, location, mood, activities, and predictions about the next day that provide personal insights into daily pain dynamics. The visualization of data and its trends over time is meant to empower individual users’ self-management of their pain. This paper outlines the scientific, clinical, technological, and user considerations involved in the development of SOMAScience and how it can be used in clinical studies or for pain self-management purposes. Our goal is for SOMAScience to provide a much-needed platform for individual users to gain insight into the multidimensional features of their pain while lowering the barrier for researchers and clinicians to obtain the type of pain data that will ultimately lead to improved prevention, diagnosis, and treatment of chronic pain.

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Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study

Stynes,

Foster,

O’ Dowd

et al. 2024

Eur Spine J

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Purpose Trial data shows modest reductions in leg pain, disability and surgery avoidance following epidural steroid injections (ESI) for severe sciatica. Despite their common use, there is no clear evidence about which patients are more likely to benefit from ESI. The aim of this study was to generate consensus on potential predictors of outcome following ESI for disc-related sciatica. Methods A list of potential predictors of outcome was generated during a consensus meeting of seven experts. The items were subsequently presented in a two round on-line Delphi study to generate consensus among experts on which items are potential predictors of outcome. Consensus was defined as 70% agreement among participants. Results Sixty-one items were generated during the consensus meeting. Of ninety experts invited to participate in the on-line Delphi study, 44 (48%) and 33 (73%) took part in rounds one and two respectively. Twenty-eight additional items suggested by participants in round one were included in round two. Overall, 14 items reached consensus reflecting domains of health, medication use, pain intensity, psychosocial factors, imaging findings and type of injection. Conclusion Based on expert consensus, items that can be routinely collected in clinical practice were identified as potential predictors of outcomes following ESI.

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Individual treatment expectations predict clinical outcome after lumbar injections against low back pain

Abstract: Supplemental Digital Content is Available in the Text.Expectations about treatment outcome allow for predicting pain intensity 2 weeks after injections against low back pain.

Cited by 5 publications

References 46 publications

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

The relevance of outcome expectations in group hypnosis for stress reduction: a secondary analysis of a multicenter randomized controlled trial

SOMAScience: A Novel Platform for Multidimensional, Longitudinal Pain Assessment

Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study

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