Individual variation in diurnal cortisol in patients with knee osteoarthritis: Clinical correlates

Paschali, Myrella; Lazaridou, Asimina; Paschalis, Theodoros; Moradian, Julia R.; Sadora, Jason; Vilsmark, Eric S.; Edwards, Robert R.

doi:10.1016/j.ijpsycho.2021.06.004

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…frontiersin.org cytochrome P450 to produce glucocorticoids and mineralocorticoids, respectively, which are involved in immune regulation, maintenance of internal homeostasis, and stress mitigation (Chang et al, 2021;Yang et al, 2021). Glucocorticoids formed at the end of the hypothalamic-pituitary-adrenal (HPA) axis include cortisol (Paschali et al, 2021;Kim et al, 2022). In addition, any changes in its levels can disrupt thyroid function by affecting the levels of FT3, FT4, and TSH (Doggui, 2016;Ernst et al, 2020).…”

Section: Frontiers In Pharmacologymentioning

confidence: 99%

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

Chen,

Liang,

Zhang

et al. 2024

Front. Pharmacol.

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The pharmacodynamic substances in “Scrophulariae Radix–Fritillaria” and the molecular mechanisms underlying its therapeutic effects against goiter were analyzed through metabolomics and serum pharmaco-chemistry. A rat model of goiter was established using propylthiouracil (PTU), and the animals were treated using “Scrophulariae Radix–Fritillaria.” The efficacy of the drug pair was evaluated in terms of thyroid gland histopathology and blood biochemical indices. Serum and urine samples of the rats were analyzed by UPLC-Q-TOF/MS. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were performed to screen potential biomarkers in urine and the corresponding metabolic pathways. The blood components of “Scrophulariae Radix–Fritillaria” were also identified, and their correlation with urine biomarkers was analyzed in order to screen for potential bioactive compounds. “Scrophulariae Radix–Fritillaria” mitigated injury to thyroid tissues and normalized the levels of the thyroid hormones FT3, FT4, and TSH. We also identified 22 urine biomarkers related to goiter, of which 19 were regulated by “Scrophulariae Radix–Fritillaria.” Moreover, urine biomarkers are involved in tryptophan metabolism, steroid hormone biosynthesis, and beta-alanine metabolism, and these pathways may be targeted by the drug pair. In addition, 47 compounds of “Scrophulariae Radix–Fritillaria” were detected by serum pharmacochemistry, of which nine components, namely, syringic acid, paeonol, cedrol, and cis-ferulic acid, fetisinine, aucubigenin, linolenic acid, ussuriedine, and 5-(methylsulfanyl)pentanenitrile, were identified as potential effective substances against goiter. To summarize, we characterized the chemical components and mechanisms of “Scrophulariae Radix–Fritillaria” involved in the treatment of goiter, and our findings provide an experimental basis for its clinical application.

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Section: Frontiers In Pharmacologymentioning

confidence: 99%

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

Chen,

Liang,

Zhang

et al. 2024

Front. Pharmacol.

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show abstract

“…The same applies to several endotypes (i.e., a subtype of a disease condition, implying a distinct pathophysiological mechanism [60]). Here, the dysregulation of the wake and sleep circadian rhythm [75], the disturbance of sleep architecture [76], HPA axis dysregulation [77], and a disturbed inflammatory activity require further investigation in people with clinical OA-related pain and comorbid insomnia symptoms.…”

Section: Expanding Knowledge On Mechanisms Linking Insomnia Symptoms ...mentioning

confidence: 99%

The interplay between symptoms of insomnia and pain in people with osteoarthritis: A narrative review of the current evidence

Baets

Runge

Labie

et al. 2023

Sleep Medicine Reviews

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Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis

et al. 2022

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Individual variation in diurnal cortisol in patients with knee osteoarthritis: Clinical correlates

Cited by 9 publications

References 38 publications

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

The interplay between symptoms of insomnia and pain in people with osteoarthritis: A narrative review of the current evidence

Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis

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