Scientifically, many studies confirmed the effectiveness of Cognitive Behavior Therapy, especially for people with alcohol abuse. This study presents a literature review that examines 10 international journals published between 2000 and 2018. The purpose of this study is to examine more deeply the research subject, comorbidity of alcohol use disorders, treatment goals, research designs, treatment settings, and the development of cognitive-behavioral therapy in industry 4.0. Based on reviews that have been done, the age of alcohol abusers varies greatly, ranging from 18 to 53 years old. It was also found that alcohol abuse is commonly comorbid with insomnia, post-traumatic stress disorder, and social anxiety disorder. The treatment goals and settings also vary. In terms of research design, experimental research was mostly used to examine this issue. In this technological and digital era today, internet-based Cognitive Behavior Therapy has proven to be effective in reducing the severity or intensity of drinking alcohol. This has become a separate recommendation for developing countries.