Individualization of Antihypertensive Therapy: An Approach Based on Hemodynamics and Age

Messerli, Franz H.

doi:10.1002/j.1552-4604.1981.tb05659.x

Cited by 22 publications

(2 citation statements)

References 34 publications

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“…The hallmark of systemic arterial hypertension is increased total peripheral resistance (1). Calcium channel blocking agents relax arteriolar smooth muscle and decrease peripheral resistance and thus have theoretical advantages over beta-blockers and thiazides in the treatment of hypertension (2).…”

Section: Introductionmentioning

confidence: 99%

An Audit of Nifedipine in a Hypertension Clinic

et al. 1986

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The results of treating 235 hypertensive patients who had been prescribed nifedipine in a hypertension clinic were examined for factors affecting blood pressure response and the frequency of side-effects. Pretreatment systolic and diastolic blood pressure correlated significantly with the decrease in blood pressure but this effect was lost following statistical correction. No relation was found between response and age or race nor did any biochemical or haematological parameter predict the antihypertensive effect. Fifty-nine (257;) patients complained of side-effects which were dose related; the drug had to be discontinued in 30 patients (13%) but the remaining 29 continued at the same or reduced dosage. Small, but statistically significant, elevations were seen in serum albumin, alkaline phosphatase and bilirubin as well as a rise in average blood glucose levels.Although side-effects are fairly common nifedipine is an effective antihypertensive drug when given alone or in combination with other therapies.

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Section: Introductionmentioning

confidence: 99%

An Audit of Nifedipine in a Hypertension Clinic

et al. 1986

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“…The peripheral arterial resistance is considered the hemodynamic hallmark for the severity of arterial hypertension [5]. …”

Section: Introductionmentioning

confidence: 99%

Renal Vascular Resistance in Essential Hypertension

Gales̃ić

Brkljačić

Božikov

et al. 1998

Nephron

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Treatment of Hypertension in the Elderly with Labetalol

1989

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Elderly and young hypertensive patients differ with regard to clinical and pathophysiologic profiles. In the elderly, hypertension is generally characterized by elevated peripheral vascular resistance and decreased cardiac output. To establish an individualized or patient-specific approach to their treatment, antihypertensive agents must be evaluated specifically in this subpopulation. Labetalol, an alpha- and beta-blocking agent, has been shown to lower blood pressure in young and elderly hypertensive patients primarily by reducing peripheral vascular resistance without compromising cardiac output. Examination of recent reports on the pharmacokinetics and pharmacodynamic effects, and on the efficacy and safety of labetalol in elderly persons with hypertension, leads us to conclude that the drug appears to be well suited for use in these patients.

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Individualization of Antihypertensive Therapy: An Approach Based on Hemodynamics and Age

Cited by 22 publications

References 34 publications

An Audit of Nifedipine in a Hypertension Clinic

An Audit of Nifedipine in a Hypertension Clinic

Renal Vascular Resistance in Essential Hypertension

Treatment of Hypertension in the Elderly with Labetalol

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