Individualized Biological Age as a Predictor of Disease: Korean Genome and Epidemiology Study (KoGES) Cohort

An, Seokyung; Ahn, Cheol‐Hee; Moon, Sungji; Sim, Eun Ji; Park, Sue Kyung

doi:10.3390/jpm12030505

Cited by 14 publications

(7 citation statements)

References 46 publications

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“…Studying individuals who are considered generally healthy at baseline, as is the case in this case series as well as the original pilot study, may have removed potential confounding from disease-accelerated biological aging and instead limited the investigation to the influence of the intervention on aging itself. It has been documented that those with chronic disease, such as type 2 diabetes, have epigenetic methylation patterns that are consistent with being biologically older than their disease-free counterparts, and that those with a higher biological age who are presently disease-free are at greater risk of developing a chronic disease [ 10 , 11 ]. In addition, it has been observed in large data sets that positive lifestyle factors as well as effective medical treatment correlate with a reduced biological age in those with type 2 diabetes (Preprint) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series

Fitzgerald¹,

Campbell

Makarem

et al. 2023

Aging

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Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. The intervention consisted of an 8-week program that included diet, sleep, exercise and relaxation guidance, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the 8-week period. Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.

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Section: Discussionmentioning

confidence: 99%

Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series

Fitzgerald¹,

Campbell

Makarem

et al. 2023

Aging

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“…According to the trends described in the present study, hospitalizations due to HF, IHD, and CeVD in PLWH increased while overall hospitalizations of PLWH decreased. This is likely related to the impact of highly effective antiretroviral therapy, which allowed PLWH to have near-normal life expectancy and resulted in a rise in morbidity and mortality associated with age-related causes[ 20 , 21 ]. The dramatic changes brought about by antiretroviral therapy is shown by how the annual mortality of PLWH exceeded 20% prior to 1996 but declined to less than 2% only after a decade later[ 22 ].…”

Section: Discussionmentioning

confidence: 99%

National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus

Park¹,

An²,

Romero³

et al. 2022

WJC

Self Cite

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BACKGROUND As people living with human immunodeficiency virus (HIV) (PLWH) enjoy longer life expectancy with highly effective antiretroviral therapy, they are encountering challenging cardiovascular health risks. AIM To retrospectively examine the increasing burden of cardiovascular diseases in PLWH over the past decade. METHODS All hospitalizations for heart failure (HF), ischemic heart disease (IHD), and cerebrovascular disease (CeVD) in PLWH were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CM codes in the National Inpatient Sample from 2008 to 2018. Outcomes included number of hospitalizations, in-hospital mortality, length of stay, and total hospital charge. Trend of the outcomes from 2008 to 2018 were analyzed using Cochran-Armitage trend test and simple linear regression. RESULTS The number of hospitalizations for HF in PLWH increased from 4212 in 2008 to 6700 in 2018 ( P trend < 0.01). Similar increasing trend was seen with those for IHD and CeVD over the decade ( P trend < 0.01). A decreasing trend of in-hospital mortality was observed in all hospitalizations of PLWH ( P trend < 0.01) and CeVD in PLWH ( P trend < 0.01), but not in those for HF ( P trend = 0.67) and IHD ( P trend = 0.13). The trend of length of stay was decreasing in all hospitalizations of PLWH ( P trend < 0.01), but increasing in those for HF in PLWH ( P trend < 0.01). An increasing trend of total hospital charge was observed in hospitalizations for HF, IHD, and CeVD ( P trend < 0.01). CONCLUSION The burden of cardiovascular diseases has significantly increased in hospitalizations of PLWH from 2008 to 2018. Continued efforts are needed to address the additional cardiovascular risks in this vulnerable population.

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“…Studying individuals who are considered generally healthy at baseline, as is the case in this case series as well as the original pilot study, may have removed potential confounding from diseaseaccelerated biological aging and instead limited the investigation to the influence of the intervention on aging itself. It has been documented that those with chronic disease, such as type 2 diabetes, have epigenetic methylation patterns that are consistent with being biologically older than their disease-free counterparts, and that those with a higher biological age who are presently disease-free are at greater risk of developing a chronic disease [10,11]. In addition, it has been observed in large data sets that positive lifestyle factors as well as effective medical treatment correlate with a reduced biological age in those with type 2 diabetes (Preprint) [11].…”

Section: Significance Of Studying Healthy Individualsmentioning

confidence: 99%

Reduction of biological age following an 8-week methylation-supportive diet and lifestyle program: A case series

Fitzgerald¹,

Campbell²,

Makarem³

et al. 2023

Preprint

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Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. This is a follow-up report to a paper that was published in Aging in April 2021 entitled: Potential reversal of epigenetic age using a diet and lifestyle intervention: A pilot randomized clinical trial (linked here: https://www.aging-us.com/article/202913/text), using an intervention that was largely the same as the aforementioned pilot trial but in a different study population. The intervention consisted of an 8-week program that included diet, sleep, exercise and relaxation guidance, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the 8-week period. Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants’ mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.

show abstract

Individualized Biological Age as a Predictor of Disease: Korean Genome and Epidemiology Study (KoGES) Cohort

Cited by 14 publications

References 46 publications

Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series

Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series

National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus

Reduction of biological age following an 8-week methylation-supportive diet and lifestyle program: A case series

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