Individualized fluid management in extremely preterm neonates to ensure adequate diuresis without increasing complications

Havinga, Jaclyn; Williams, Allison; Hassan, Neha; Moore, Sheva; Dollhopf, Emma; Tumin, Dmitry; Akpan, Uduak S.

doi:10.1038/s41372-020-00789-7

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Both being small for gestational age and having higher fluid intake/retention in the first week of life are important risk factors for BPD. [44][45][46][47][48] Although these potential explanations are reasonable, it must be noted that the mean percent weight loss between birth and start of feeds was similar between the cohorts (5.9% ± 6.7% vs 6.1% ± 6.1%, P = .93), and the Novel HMF group continued to be smaller for age at feeding initiation when compared with the Bovine HMF group. A limitation to our study was that the weight, length, and head circumference measurements for the retrospective cohort group…”

Section: Discussionmentioning

confidence: 92%

“…Furthermore, it is plausible that an earlier RTBW reflects a shorter diuretic phase and potentially greater fluid retention in the immediate postpartum period. Both being small for gestational age and having higher fluid intake/retention in the first week of life are important risk factors for BPD 44–48 . Although these potential explanations are reasonable, it must be noted that the mean percent weight loss between birth and start of feeds was similar between the cohorts (5.9% ± 6.7% vs 6.1% ± 6.1%, P = .93), and the Novel HMF group continued to be smaller for age at feeding initiation when compared with the Bovine HMF group.…”

Section: Discussionmentioning

confidence: 93%

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Novel multinutrient human milk‐based human milk fortifier promotes growth and tolerance in premature infants

Gates

Thompson

Marin

et al. 2021

J Parenter Enteral Nutr

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Background:The objective of this study was to determine whether human milk supplemented with a novel human milk-based human milk fortifier (Novel HMF), compared with a bovine milk-based HMF (Bovine HMF), supports preterm infant growth through 36 weeks' postmenstrual age (PMA).Methods: This single-center, prospective trial compared growth and nutrition outcomes of preterm infants provided a human milk-based diet (mother's own milk or donor milk) supplemented with a Novel HMF with historic controls provided Bovine HMF. Preterm infants with an estimated gestational age (EGA) between 23 and 33 weeks' PMA and birth weight between 750 and 1800 g were eligible for study inclusion. Weight, length, and head circumference (HC) were monitored weekly. The occurrence of late-onset sepsis, nil per os (NPO) days, necrotizing enterocolitis, metabolic acidosis, and serious adverse events were monitored.Results: Birth weight, length, HC, and EGA were similar between the Novel HMF (n = 37) and Bovine HMF (n = 49) groups. The days to regain birth weight was shorter in the Novel HMF group (9.4 ± 4.0 vs 11.4 ± 4.8, P = .0343), with similar weight gain (g/day) from birth to 36 weeks' PMA. Adjusted weight growth velocity (g/kg/day) was significantly higher in the Novel HMF group at 14 and 21 days but similar at 36 weeks' PMA. The Novel HMF group experienced fewer NPO days with a similar total number of feeding days.Conclusions: A novel, multinutrient, human milk-based HMF is well tolerated and meets the nutrition needs of preterm infants.

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