2020
DOI: 10.1186/s12957-020-01972-y
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Individualized prediction of survival benefit from primary tumor resection for patients with unresectable metastatic colorectal cancer

Abstract: Background: The impact of primary tumor resection (PTR) on the prognosis of unresectable metastatic colorectal cancer (mCRC) patients remains debatable. We aimed to develop several prognostic nomograms which could be useful in predicting whether patients might benefit from PTR or not. Methods: Patients diagnosed as mCRC without resected metastasis were identified from the Surveillance Epidemiology and End Results database and randomly assigned into two groups: a training cohort (6369 patients) and a validation… Show more

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Cited by 7 publications
(7 citation statements)
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“…Previously, the effect of tumor location on the prognosis of patients with unresectable metastatic CRC was compared between two or three groups mostly according to “right colon and left colon” and “right colon, left colon and rectum” [ 22 26 ]. However, more and more studies proved that a simple classification into right- and left-sided CRC could not represent the complexity of this tumor entity, and put forward the importance of researching from the perspective of colonic subsites [ 27 29 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Previously, the effect of tumor location on the prognosis of patients with unresectable metastatic CRC was compared between two or three groups mostly according to “right colon and left colon” and “right colon, left colon and rectum” [ 22 26 ]. However, more and more studies proved that a simple classification into right- and left-sided CRC could not represent the complexity of this tumor entity, and put forward the importance of researching from the perspective of colonic subsites [ 27 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…Refer to the published literature [ 21 , 22 ], we considered patients who did not have resection of liver metastases as unresectable CRLM. All patients were divided into three major cohorts: UHFLM, UTCLM, and USFLM cohorts.…”
Section: Methodsmentioning
confidence: 99%
“…In 2019, colorectal cancer was estimated to be the highest cancer incidence and death rate in the United States 1 . In general, surgical resection, endoscopic therapy, and neoadjuvant therapy have become the main treatment methods for different stages of colorectal cancer 2,[3][4][5] . With the widespread application of endoscopic screening, more colon cancer patients have been identi ed at an early stage in recent years.…”
Section: Read Full License Introductionmentioning
confidence: 99%
“…1 In general, surgical resection, endoscopic therapy, and neoadjuvant therapy have become the main treatment methods for different stages of CRC. [2][3][4][5] With the widespread application of endoscopic screening, more CC patients have been identified at an early stage in recent years. According to the American Joint Committee on Cancer (AJCC) staging manual, T1 CC refers to submucosal invasive carcinoma.…”
Section: Introductionmentioning
confidence: 99%