Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study

Cinotti, Raphaël; Asehnoune, Karim; Stevens, Robert; Taccone, Fabio Silvio; Pelosi, Paolo; Abback, Paër-Sélim; Codorniu, Anaïs; Citerio, Giuseppe; Sala, V.; Astuto, Marinella; Tringali, Eleonora; Alampi, Daniela; Rocco, Monica; Maugeri, Jessica Giuseppina; Bellissima, Agrippino; Filippini, Matteo; Lazzeri, Nicoletta; Cortegiani, Andrea; Ippolito, Mariachiara; Robba, Chiara; Battaglini, Denise; Biston, Patrick; Al-Gharyani, Mohamed Fathi; Chabanne, Russell; Astier, Léo; Soyer, Benjamin; Gaugain, Samuel; Zimmerli, Alice; Pietsch, Urs; Filipovic, Miodrag; Brandi, Giovanna; Bicciato, Giulio; Serrano, Ainhoa; Monleon, Berta; Vliet, Peter Van de; Gerretsen, Benjamin Marcel; Ortiz-Macias, Iris Xochitl; Oto, Jun; Enomoto, Noriya; Matsuda, Tomomichi; Masui, Nobutaka; Garçon, Pierre; Zarka, Jonathan; Vermeijden, Wytze J.; Cornet, Alexander D.; Inurrigarro, S. Reyes; Domínguez, Rafael Cirino Lara; Bellini, Maria Mercedes; Gomez-Haedo, Maria Milagros; Lamot, Laura; Orquera, Jose; Biais, Matthieu; Georges, Delphine; Baronia, Arvind Kumar; Miranda-Ackerman, Roberto Carlos; Barbosa-Camacho, Francisco José; Porter, John M.; Lopez-Morales, Miguel; Geeraerts, Thomas; Compagnon, Baptiste; Pérez-Torres, David; Prol-Silva, Estefanía; Yahya, Hana Basheer; Khaled, Ala; Ghula, Mohamed; Neville, A. Munro; Palma, Maria Ilaria; Deana, Cristian; Vetrugno, Luigi; Chavez, Manuel J. Rivera; Trujillo, Rocio Mendoza; Legros, Vincent; Brochet, Benjamin; Huet, Olivier; Geslain, Marie; Ahmed, Hazem; Coombs, Alexander Edward; Welbourne, Jessie; Pineda, Ana Alicia Velarde; Castillo, Víctor Hugo Nubert; Azzam, Ahmed Y; Meenen, David M. P. van; Galicia-Espinosa, Forttino; García-Ramos, José Carlos; Yadav, Ghanshyam; Jha, Amarendra Kumar; Robert-Edan, Vincent; Rodie-Talbere, Pierre-André; Jain, Gaurav; Panda, Sagarika; Agarwal, Sonika; Deewan, Yashbir; Gasca, Gilberto Adrian; Arellano, A.; Hossain, Md. Mozaffer; Papadas, Christos; Chantziara, Vasiliki; Sklavou, Chrysanthi; Hourmant, Yannick; Grillot, Nicolas; Steenkiste, Job van; Jagt, Mathieu van der; Pirracchio, Romain; Akkari, Abdelraouf; Abdelaty, Mohamed; Hashim, Ahmed; Launey, Yoann; Masseret, Élodie; Lasocki, Sigismond; Gergaud, Soizic; Mouclier, Nicolas; Saxena, Sulekha; Agrawal, Avinash; Mishra, Shakti Bedanta; Samal, Samir; Mijangos, Julio Cesar; Haënggi, Mattias; Gurjar, Mohan; Schultz, Marcus J.; Kaye, Callum; Godoy, D.A.; Alvarez, Pablo; Ioakeimidou, Aikaterini; Ueno, Yoshio; Badenes, Rafael; Elbuzidi, Abdurrahmaan Ali Suei; Piagnerelli, Michaël; Elhadi, Muhammed; Reza, Syed Tariq; Azab, Mohammed A.; Digitale, Jean; Fong, Nicholas; Cerda, Ricardo Campos; Peredo, Norma de la Torre

doi:10.1007/s12028-023-01761-x

Cited by 8 publications

(4 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two directions are found in the field of immature (or premature) organisms; on the one hand, as previously reported, some adverse normobaric hyperoxic effects may occur, but on the other hand, several sessions of hyperbaric oxygen treatment have been reported to be beneficial [29,41,42].…”

Section: Hyperbaric Hyperoxic Oxygen Levelsmentioning

confidence: 97%

See 1 more Smart Citation

Oxygen Variations—Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia—Is the Dose the Clue?

Balestra,

Mrakic-Sposta,

Virgili

2023

IJMS

View full text Add to dashboard Cite

show abstract

Section: Hyperbaric Hyperoxic Oxygen Levelsmentioning

confidence: 97%

“…Oxygen can be considered bombastic sometimes, but is also as indispensable; deeper knowledge on its biology is vital in the present day, and the simple "dose is the poison" approach is not appropriate for such a metabolically active molecule [41].…”

Section: Hyperbaric Hyperoxic Oxygen Levelsmentioning

confidence: 99%

Oxygen Variations—Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia—Is the Dose the Clue?

Balestra,

Mrakic-Sposta,

Virgili

2023

IJMS

View full text Add to dashboard Cite

show abstract

“… 32 There is no agreement on the threshold value for defining hyperoxaemia, but most authors concur on a PaO 2 of 200–300 mm Hg for severe hyperoxaemia. 10 According to recent literature, a PaO 2 as low as 195 mm Hg 33 or even 156 mm Hg 2 can be related to lower survival in patients with ABI. A U-shaped curve may accurately represent the correlation between arterial oxygenation and survival or neurological outcomes in patients with ABI, but further studies are required in this specific population.…”

Section: Introductionmentioning

confidence: 99%

“…A U-shaped curve may accurately represent the correlation between arterial oxygenation and survival or neurological outcomes in patients with ABI, but further studies are required in this specific population. 2 33 …”

Section: Introductionmentioning

confidence: 99%

Neurological outcomes and mortality of hyperoxaemia in patients with acute brain injury: protocol for a systematic review and meta-analysis

Romero-Garcia,

Robba,

Monleon

et al. 2024

BMJ Open

View full text Add to dashboard Cite

IntroductionOxygen is frequently prescribed in neurocritical care units. Avoiding hypoxaemia is a key objective in patients with acute brain injury (ABI). However, several studies suggest that hyperoxaemia may also be related to higher mortality and poor neurological outcomes in these patients. The evidence in this direction is still controversial due to the limited number of prospective studies, the lack of a common definition for hyperoxaemia, the heterogeneity in experimental designs and the different causes of ABI. To explore the correlation between hyperoxaemia and poor neurological outcomes and mortality in hospitalised adult patients with ABI, we will conduct a systematic review and meta-analysis of observational studies and RCTs.Methods and analysisThe systematic review methods have been defined according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and follow the PRISMA-Protocols structure. Studies published until June 2024 will be identified in the electronic databases MEDLINE, Embase, Scopus, Web of Science, The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials.gov. Retrieved records will be independently screened by four authors working in pairs, and the selected variables will be extracted from studies reporting data on the effect of ‘hyperoxaemia’ versus ‘no hyperoxaemia on neurological outcomes and mortality in hospitalised patients with ABI. We will use covariate-adjusted ORs as outcome measures when reported since they account for potential cofounders and provide a more accurate estimate of the association between hyperoxaemia and outcomes; when not available, we will use univariate ORs. If the study presents the results as relative risks, it will be considered equivalent to the OR as long as the prevalence of the condition is close to 10%. Pooled estimates of both outcomes will be calculated applying random-effects meta-analysis. Interstudy heterogeneity will be assessed using the I2statistic; risk of bias will be assessed through Risk Of Bias In Non-Randomised Studies of Interventions, Newcastle-Ottawa or RoB2 tools. Depending on data availability, we plan to conduct subgroup analyses by ABI type (traumatic brain injury, postcardiac arrest, subarachnoid haemorrhage, intracerebral haemorrhage and ischaemic stroke), arterial partial pressure of oxygen values, study quality, study time, neurological scores and other selected clinical variables of interest.Ethics and disseminationSpecific ethics approval consent is not required as this is a review of previously published anonymised data. Results of the study will be shared with the scientific community via publication in a peer-reviewed journal and presentation at relevant conferences and workshops. It will also be shared key stakeholders, such as national or international health authorities, healthcare professionals and the general population, via scientific outreach journals and research institutes’ newsletters.

show abstract

Setting the ventilator in acute brain injury

Cinotti,

Taran,

Stevens

2024

Intensive Care Med

View full text Add to dashboard Cite

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study

Cited by 8 publications

References 59 publications

Oxygen Variations—Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia—Is the Dose the Clue?

Oxygen Variations—Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia—Is the Dose the Clue?

Neurological outcomes and mortality of hyperoxaemia in patients with acute brain injury: protocol for a systematic review and meta-analysis

Setting the ventilator in acute brain injury

Contact Info

Product

Resources

About