Individually Tailored Modular “Egg” Hydrogels Capable of Spatiotemporally Controlled Drug Release for Spinal Cord Injury Repair

Sun, Xiaoying; Xiong, Tao; Yang, Keni; Wang, Lei; Yang, Wen; Zhao, Haitao; Gao, Xu; You, Zhifeng; Zhuang, Yan; Chen, Yanyan

doi:10.1002/adhm.202301169

Cited by 7 publications

(2 citation statements)

References 74 publications

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“…LOCS released ≈36.75% ± 2.01% of CBD-NT3 after 7 days, nevertheless, the PCFS showed a lower cargo release rate (18.53% ± 1.96%) after 7 days of exposure, indicating that PCFS can postpone cargo release and accomplish long-term therapeutic impact (Figure S12, Supporting Information). As our previous studies observed, [36] endogenous NSCs started to migrate to the lesion sites once the injury occurred, massively proliferated, and reached a maximum amount on the 3rd −8th day after SCI. Thus, CBD-NT3 sustainably released from PCFS for at least 7 days would benefit the immigrated NSCs, which better matched the migration phase after SCI.…”

Section: Pcfs Loaded With Cbd-nt3 Accelerated the Long-term Locomotor...supporting

confidence: 71%

Biomimetic Dual‐Network Collagen Fibers with Porous and Mechanical Cues Reconstruct Neural Stem Cell Niche via AKT/YAP Mechanotransduction after Spinal Cord Injury

Zhao,

Xiong,

Chu

et al. 2024

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Tissue engineering scaffolds can mediate the maneuverability of neural stem cell (NSC) niche to influence NSC behavior, such as cell self‐renewal, proliferation, and differentiation direction, showing the promising application in spinal cord injury (SCI) repair. Here, dual‐network porous collagen fibers (PCFS) are developed as neurogenesis scaffolds by employing biomimetic plasma ammonia oxidase catalysis and conventional amidation cross‐linking. Following optimizing the mechanical parameters of PCFS, the well‐matched Young's modulus and physiological dynamic adaptability of PCFS (4.0 wt%) have been identified as a neurogenetic exciter after SCI. Remarkably, porous topographies and curving wall‐like protrusions are generated on the surface of PCFS by simple and non‐toxic CO2 bubble‐water replacement. As expected, PCFS with porous and matched mechanical properties can considerably activate the cadherin receptor of NSCs and induce a series of serine‐threonine kinase/yes‐associated protein mechanotransduction signal pathways, encouraging cellular orientation, neuron differentiation, and adhesion. In SCI rats, implanted PCFS with matched mechanical properties further integrated into the injured spinal cords, inhibited the inflammatory progression and decreased glial and fibrous scar formation. Wall‐like protrusions of PCFS drive multiple neuron subtypes formation and even functional neural circuits, suggesting a viable therapeutic strategy for nerve regeneration and functional recovery after SCI.

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Section: Pcfs Loaded With Cbd-nt3 Accelerated the Long-term Locomotor...supporting

confidence: 71%

Biomimetic Dual‐Network Collagen Fibers with Porous and Mechanical Cues Reconstruct Neural Stem Cell Niche via AKT/YAP Mechanotransduction after Spinal Cord Injury

Zhao,

Xiong,

Chu

et al. 2024

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“…[ 2c,142,146 ] In addition, the use of biomaterials for controlled release of signaling molecules, both temporally and spatially, has been enthusiastically pursued for the regeneration of MSK and nerve tissues. [ 147 ]…”

Section: Msk Regeneration With Innervated Engineered Tissuesmentioning

confidence: 99%

Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling

Zhou,

Liu,

Xiong

et al. 2024

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Musculoskeletal (MSK) disorders significantly burden patients and society, resulting in high healthcare costs and productivity loss. These disorders are the leading cause of physical disability, and their prevalence is expected to increase as sedentary lifestyles become common and the global population of the elderly increases. Proper innervation is critical to maintaining MSK function, and nerve damage or dysfunction underlies various MSK disorders, underscoring the potential of restoring nerve function in MSK disorder treatment. However, most MSK tissue engineering strategies have overlooked the significance of innervation. This review first expounds upon innervation in the MSK system and its importance in maintaining MSK homeostasis and functions. This will be followed by strategies for engineering MSK tissues that induce post‐implantation in situ innervation or are pre‐innervated. Subsequently, research progress in modeling MSK disorders using innervated MSK organoids and organs‐on‐chips (OoCs) is analyzed. Finally, the future development of engineering innervated MSK tissues to treat MSK disorders and recapitulate disease mechanisms is discussed. This review provides valuable insights into the underlying principles, engineering methods, and applications of innervated MSK tissues, paving the way for the development of targeted, efficacious therapies for various MSK conditions.

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Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

Xiao,

Dai,

et al. 2024

Adv Funct Materials

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Photothermal hydrogels (PTHs) are considered next‐generation biomaterials as they offer remotely defined biophysical information of the extracellular milieu. PTHs allow precise and non‐genetic control for the regeneration of native tissues, which is the ultimate goal of tissue engineering (TE). Molecular and physical properties of PTHs, such as components, structural configurations, and mechanical characteristics, collectively serve as determinants for understanding the dynamic tissue response and clinical translation. PTHs have entered a period of fruition due to the development of numerous manufacturing technologies and polymeric matrices. Herein, this review comprehensively and meticulously elucidates the mechanisms of regenerative therapeutics underlying the design and fabrication of PTHs. Recent advances in the photothermal principles and various categories of photothermal agents (PTAs) have been extensively discussed. Vital components and structures of PTHs are summarized to enable efficacious and precise therapeutic energy delivery. Emerging applications of PTHs in TE are also demonstrated, which expand the strategies for the intrinsic regeneration of injured tissues. Then deliberate the structural and chemical engineering of PTHs to enhance prognosis while highlighting the challenges associated with clinical translation. In this review, we aim to provide guidance and prospects for exploration and innovation of PTHs in the field of TE.

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Individually Tailored Modular “Egg” Hydrogels Capable of Spatiotemporally Controlled Drug Release for Spinal Cord Injury Repair

Cited by 7 publications

References 74 publications

Biomimetic Dual‐Network Collagen Fibers with Porous and Mechanical Cues Reconstruct Neural Stem Cell Niche via AKT/YAP Mechanotransduction after Spinal Cord Injury

Biomimetic Dual‐Network Collagen Fibers with Porous and Mechanical Cues Reconstruct Neural Stem Cell Niche via AKT/YAP Mechanotransduction after Spinal Cord Injury

Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling

Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

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