Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study

Rodríguez-López, Mariana L; Martínez‐Magaña, José Jaime; Ruíz-Ramos, David; García, Ana Rosa Sepúlveda; González, Laura; Tovilla‐Zárate, Carlos Alfonso; Sarmiento, Emmanuel; Juárez‐Rojop, Isela Esther; Nicolini, Humberto; González‐Castro, Thelma Beatriz; Genis‐Mendoza, Alma Delia

doi:10.3390/nu13051413

Cited by 12 publications

(3 citation statements)

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“…Ancak 2021 Nisan ayında yayınlananbir çalışma, 21 TYB ve 25 BN tanısı alan bireyler arasındaki genom çapında DNA metilasyon farklılıklarını analiz etmiş. Sonuç olarak TYB ve BN'li bireyler arasında genom çapında, önemli 11 farklı DNA metilasyon bölgesi tespit etmişler ayrıca TYB olan olguların metabolik fonksiyonlarla ilgili olan ST3GAL4, PRKAG2 ve FRK genlerinde hipomentilasyona rastlarken BN'li olgularda ise böyle bir sonuç elde etmemişlerdir (65).…”

Section: Yb'de Dna Metilasyonu üZerine Bulgularunclassified

Ajitasyon ve Acil Serviste Yönetimi

Yildiz¹,

Selvi²,

Bedel³

et al. 2023

Sağlık Bilimleri Alanında Uluslararası Araştırmalar-Ii

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ÖzetEkinokok enfeksiyonlarında iskelet sistemi tutulumu nadirdir. İskelet tutulumu genellikle enfeksiyonun hematojen yayılımından sonra sekonder yayılıma bağlıdır. Vertebral kolon, kotlar, pelvis ve kafatası en sık tutulan bölgelerdir. Vertebral tutulum tüm olguların %1'inde görülen nadir bir tutulumdur. Karakteristik belirti veya semptomları yoktur. Tercih edilen tedavi cerrahi olup, cerrahi tedavinin mümkün olmadığı ve cerrahi tedaviye ek olarak medikal tedavi düzenlenir. GİRİŞEchinococcus cinsi parazitler tenya cinsinden bir helmint olup, kist hidatik (KH) hastalığına neden olur. En sık (%90) karaciğer tutulumuna neden olmak üzere birçok farklı organ veya dokuyu tutabilir (1). Echinococcus cinsinin dört türü vardır: E. granulosus, E. alveolaris (multilocularis), E. voegeli ve E. oligarthrus (2,3). Sadece E. alveolaris ve E. granulosus insan enfeksiyonları için önemlidir ve sık görülür (2). E. granulosis en sık etkendir, E. alveolaris enfeksiyonları daha nadirdir (4). Ancak alveolar ekinokokkoz daha infiltratif bir hastalık oluşturur. Primer lezyon tipik olarak karaciğerde lokalizedir. Hastalık malign ve infiltratif özellik gösterir (5). Moleküler çalışmalara ve DNA dizilimine dayalı olarak, E. granulosus 10 farklı genotip (G1 ila G10) halinde sınıflandırılmıştır (6).Echinococcus cinsi parazitler yaşam döngüsünü tamamlamak için insanı ara konak olarak kullanır. Yetişkin E. granulosus köpeklerin, kurtların, tilki-

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Section: Yb'de Dna Metilasyonu üZerine Bulgularunclassified

Ajitasyon ve Acil Serviste Yönetimi

Yildiz¹,

Selvi²,

Bedel³

et al. 2023

Sağlık Bilimleri Alanında Uluslararası Araştırmalar-Ii

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“…Interestingly, two recent studies reported differential levels of DNA methylation in several sites of the OXTR gene in female patients with AN as compared to females remitted from AN and healthy females, and DNA methylation was correlated with markers of AN severity [ 13 , 26 ]. However, only two studies so far investigated epigenetic alterations in patients with binge eating, but the OXTR was not included, and samples were heterogeneous [ 28 , 29 ] and small (< 30 cases) [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder

Giel¹,

Schag²,

Leehr

et al. 2022

Clin Epigenet

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Background The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is altered in patients with eating and weight disorders, and a variant of the oxytocin receptor gene (OXTR) has been associated with impulsive eating behavior as it is seen in patients with binge eating disorder (BED). Gene × environment interactions could play a role in BED. One mechanism mediating this interaction is the epigenetic alteration of gene expression. We therefore investigated if DNA methylation of the OXTR differs between individuals with obesity depending on a comorbid BED. We analyzed DNA methylation of the OXTR in peripheral blood of 227 individuals on the obesity spectrum (mean age: 40.3 ± 13.1 yrs; mean BMI: 38.6 ± 7.3 kg/m2), 130 of which were diagnosed with BED. Results There were no overall differences in OXTR methylation between participants with and those without BED (p > 0.05), while both subgroups were comparable regarding age and body mass index (BMI), but significantly differed in sex distribution (p = 0.035). We found no relationship between mean DNA methylation and BMI or self-reported eating disorder (ED) pathology. Analyzing potential sex differences revealed a significantly lower OXTR DNA methylation in male participants with BED as compared to those without BED (p = 0.017). No such difference was found in the female subsample (p > 0.05). Conclusions Clinically significant binge eating pathology might be associated with lower OXTR DNA methylation exclusively in males. The differential DNA methylation of OXTR in males with BED supports the view that BED represents a phenotype within the obesity spectrum that is characterized by specific vulnerability factors. A better understanding of the epigenetic underpinnings of the OXT system might contribute to the refinement of OXT administration approaches as potential interventions in eating and weight disorders.

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“…In addition, genetic associations between ED and substance use have been described [ 6 ]. Additionally, the genetic-environment relationship in ED has been studied through DNA methylation, reporting perturbations in the methylation levels of some genes ( DRD2 , SLC6A3 , POMC , OXTR , among others) [ 2 , 7 , 8 ]. However, genes do not function alone: on average, each gene is estimated to interact with another four or eight genes, and to be involved with 10 biological functions.…”

Section: Introductionmentioning

confidence: 99%

Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results

et al. 2021

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Eating disorders are psychiatric disorders characterized by disturbed eating behaviors. They have a complex etiology in which genetic and environmental factors interact. Analyzing gene-environment interactions could help us to identify the mechanisms involved in the etiology of such conditions. For example, comethylation module analysis could detect the small effects of epigenetic interactions, reflecting the influence of environmental factors. We used MethylationEPIC and Psycharray microarrays to determine DNA methylation levels and genotype from 63 teenagers with eating disorders. We identified 11 comethylation modules in WGCNA (Weighted Gene Correlation Network Analysis) and correlated them with single nucleotide polymorphisms (SNP) and clinical features in our subjects. Two comethylation modules correlated with clinical features (BMI and height) in our sample and with SNPs associated with these phenotypes. One of these comethylation modules (yellow) correlated with BMI and rs10494217 polymorphism (associated with waist-hip ratio). Another module (black) was correlated with height, rs9349206, rs11761528, and rs17726787 SNPs; these polymorphisms were associated with height in previous GWAS. Our data suggest that genetic variations could alter epigenetics, and that these perturbations could be reflected as variations in clinical features.

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Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study

Cited by 12 publications

References 82 publications

Ajitasyon ve Acil Serviste Yönetimi

Ajitasyon ve Acil Serviste Yönetimi

OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder

Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results

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