Indocyanine green‐augmented diode laser therapy of telangiectatic leg veins: A randomized controlled proof‐of‐concept trial

Abstract

ICG-augmented diode laser therapy has proved to be a safe and effective treatment option for telangiectatic leg veins.

Indocyanine green-augmented diode laser therapy vs. long-pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial

“…If the vessel was still visible after the first DL pulse, a second pulse was applied at the same site (double pulse). Double pulses and radiant exposures of 60–110 J cm −2 were shown to be efficacious and safe in our pilot trial . At 808 nm there is nearly no absorption of radiation in water, but the absorbing chromophore (ICG) is located exclusively within the vessel.…”

“…The vessel temperature was up to 45 °C higher when ICG was added at a dose of 1 or 2 mg kg −1 prior to laser irradiation . We have recently shown that ICG+DL therapy may be a new treatment option for capillary malformations and TLV . Based on these investigations, we compared the impact of ICG+DL therapy at a total dose of 4 mg kg −1 with the standard treatment, Nd:YAG laser therapy, in 29 participants with TLV in a randomized controlled clinical trial.…”

“…8 We have recently shown that ICG+DL therapy may be a new treatment option for capillary malformations and TLV. 9,10 Based on these investigations, we compared the impact of ICG+DL therapy at a total dose of 4 mg kg À1 with the standard treatment, Nd:YAG laser therapy, in 29 participants with TLV in a randomized controlled clinical trial. To the best of our knowledge, this study is the first trial in the literature comparing ICG+DL therapy of TLV with long-pulsed Nd:YAG laser treatment.…”

Neue Entwicklungen in der Lasertherapie

“…Diese Ergebnisse konnten in einer weiteren Anwendung durch mathematische Modellberechnungen bestätigt werden [35]. Die klinische Etablierung der ICG-augmentierten Lasertherapie gelang weltweit erstmalig im letzten Jahr in der Regensburger Hautklinik im Rahmen zweier "investigator initiated trials" [58,59]. Im Rahmen dieser randomisierten, kontrollierten klinischen Studien wurden Patienten mit Feuermalen (n = 31) und Besenreisern (n = 15) erfolgreich mittels ICG-augmentierter Diodenlasertherapie behandelt.…”

“…Unerwünschte Arzneimittelwirkungen im Rahmen der ICGApplikation traten nicht auf. Lokale Komplikationen wie Wundheilungsstörungen, Blasen-oder Krustenbildung, Pigmentverschiebungen oder Narbenbildung zeigten sich lediglich in einem Fall in Form eines Närbchens [58,59].…”