Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure

American Gastroenterological Association Institute Technical Review on Initial Testing and Management of Acute Liver Disease

“…The construction of the hierarchical summary receiver-operator curves suggest that MELD may have more opportunity to maximize overall utility if more attempts are made to increase specificity because the curve was flat, suggesting not much sensitivity will be sacrificed (Figure 1 and Table 2). Similar results can be seen if we compare the 4 studies [79][80][81]83 that directly evaluated the performance of KCC and MELD in the same ALF population.…”

“…We identified 6 studies [79][80][81]83,86,87 evaluating 526 ALF patients and, overall, 304 (58%) died. All studies did not have liver transplantation available so this eliminates bias owing to competing outcomes but the samples were not representative of Western populations (causes of ALF and management will be different).…”

Acetaminophen hepatotoxicity: an updated review

“…In humans, ICG clearance combined with MELD scores showed superior results in predicting 3-month mortality compared to MELD alone or the King's College Criteria. This study, however, was performed in patients with hepatitis B as the most common cause of ALF (Feng et al 2014).…”

Human Ex-Vivo Liver Model for Acetaminophen-induced Liver Damage

“…Furthermore, a recent study demonstrated a better accuracy to predict 3-month mortality in ALF patients for a combination of ICG testing and the model-for-end-stage liver disease score than conventional scores13. Thus, we are confident that ICG is sufficient to determine liver damage in the presented system even though transaminases did not indicate differences in damage.…”