Indocyanine Green Loaded PLGA Film Coated Coronary Stents for Photo-Triggered in situ Biofilm Eradication

Vögeling, Hendrik; Pinnapireddy, Shashank Reddy; Seitz, Benjamin Sebastian

doi:10.1016/j.colcom.2018.10.002

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…Vascular and coronary stent insertion is accompanying with the risk of microbial biofilm formation, which can cause serious infectious diseases. Another risk of coronary stents is cell ingrowth into the stent and restoration of stenosis [37,38].…”

Section: Stentsmentioning

confidence: 99%

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

et al. 2019

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Biodegradable polymers are promising materials for use in medical applications such as stents. Their properties are comparable to commercially available resistant metal and polymeric stents, which have several major problems, such as stent migration and stent clogging due to microbial biofilm. Consequently, conventional stents have to be removed operatively from the patient’s body, which presents a number of complications and can also endanger the patient’s life. Biodegradable stents disintegrate into basic substances that decompose in the human body, and no surgery is required. This review focuses on the specific use of stents in the human body, the problems of microbial biofilm, and possibilities of preventing microbial growth by modifying polymers with antimicrobial agents.

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Section: Stentsmentioning

confidence: 99%

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

et al. 2019

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“…Indocyanine green (ICG), an FDA approved near-infrared (NIR) fluorescent dye, has been clinically applied in the diagnosis of liver function owing to its active liver targeting property [ [37] , [38] ]. [[, 38 ] [] [37] , [38] [] Moreover, ICG is a photosensitizing agent that has been frequently used for photodynamic therapy (PDT) based on its ability to produce reactive oxygen species (ROS) under NIR laser irradiation [ [39] , [40] ]. [[, 40 ] [] [39] , [40] [] Amusingly, ICG-based nanoscale coordination particles have demonstrated prominent performance in the control of bacterial infection, which has led to little antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

“…[[, 38 ] [] [37] , [38] [] Moreover, ICG is a photosensitizing agent that has been frequently used for photodynamic therapy (PDT) based on its ability to produce reactive oxygen species (ROS) under NIR laser irradiation [ [39] , [40] ]. [[, 40 ] [] [39] , [40] [] Amusingly, ICG-based nanoscale coordination particles have demonstrated prominent performance in the control of bacterial infection, which has led to little antibiotic resistance. The membrane components of bacteria could be damaged by the generated ROS so that the antibacterial gallium component can enter and play a synergistic therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall Ga-ICG nanoparticles based gallium ion/photodynamic synergistic therapy to eradicate biofilms and against drug-resistant bacterial liver abscess

Xie

et al. 2021

Bioactive Materials

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Pyogenic liver abscess and keratitis are aggressive bacterial infections and the treatment has failed to eradicate bacteria in infectious sites completely owing to the currently severe drug resistance to existing antibiotics. Here, we report a simple and efficient one-step development of ultrasmall non-antibiotic nanoparticles (ICG-Ga NPs) containing clinically approved gallium (III) (Ga 3+ ) and liver targeting indocyanine green (ICG) molecules to eradicate multi-drug resistant (MDR) bacteria thought the synergetic effect of photodynamic therapy and iron metabolism blocking. The ICG-Ga NPs induced photodynamic effect could destroy the bacterial membrane, further boost the endocytosis of Ga 3+ , then replace iron in bacteria cells to disrupt bacterial iron metabolism, and demonstrate the synergetic bacterial killing and biofilm disrupting effects. The ICG-Ga NPs show an excellent therapeutic effect against extended spectrum β-lactamases Escherichia coli (ESBL E. coli ) and significantly improve treatment outcomes in infected liver abscess and keratitis. Meanwhile, the ultrasmall size of ICG-Ga NPs could be cleared rapid via renal clearance route, guaranteeing the biocompatibility. The protective effect and good biocompatibility of ICG-Ga NPs will facilitate clinical treatment of bacteria infected diseases and enable the development of next-generation non-antibiotic antibacterial agents.

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Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes

et al. 2019

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Indocyanine Green Loaded PLGA Film Coated Coronary Stents for Photo-Triggered in situ Biofilm Eradication

Cited by 10 publications

References 22 publications

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

Ultrasmall Ga-ICG nanoparticles based gallium ion/photodynamic synergistic therapy to eradicate biofilms and against drug-resistant bacterial liver abscess

Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes

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