Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy

Costa, R. A.; Scapucin, Luciana; Moraes, Nilva Simeren Bueno de; Calucci, Daniela; Melo, Luiz Alberto S.; Cardillo, J.A.; Farah, Michel Eid

doi:10.1076/ceyr.25.5.287.13496

Cited by 46 publications

(26 citation statements)

References 16 publications

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“…It typically affects young and middle-aged adults and is usually associated with good visual prognosis [2, 3]. The diagnosis is confirmed by fluorescein angiography and indocyanine green (ICG) angiography, which reveal the site of serous fluid leakage from RPE into the subretinal space and identify choroidal hyperpermeability and possible ischemia [2, 4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Fundus Autofluorescence before and after Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Özmert¹,

Batıoğlu²

2009

Ophthalmologica

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Background: To determine the effect of photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSCR) and to describe fundus autofluorescence (AF) patterns before and after PDT. Methods: Seven eyes of 7 patients with chronic CSCR were included. Patients underwent complete ophthalmic examination and macular optical coherence tomography (OCT) scans were taken. Fluorescein and indocyanine green angiographies and fundus AF images were obtained by Heidelberg Retinal Angiography 2 (HRA2). PDT was performed according to the standard TAP protocol on the site of leakage area and submacular fluid. The mean follow-up period was 5.4 months. Results: Submacular fluid disappeared in all eyes 1 month after PDT and there was no recurrence during the follow-up. Visual acuity increased two or more lines in 5 eyes. Hyperautofluorescence in the area of previous retinal detachment significantly increased in the first month of PDT compared to preoperative findings. After the first month during the follow-up, increased AF in the area of previous retinal elevation returned to the baseline intensity. Conclusion: PDT of CSCR may result with resolution of subretinal fluid and visual improvement. Fundus AF may be an additional tool for monitoring the functional status of retinal pigment epithelium.

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Section: Introductionmentioning

confidence: 99%

Fundus Autofluorescence before and after Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Özmert¹,

Batıoğlu²

2009

Ophthalmologica

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“…In a case series, IMP produced favourable results in patients with persistent CSC, but adverse events, such as mild and transient retinal whitening and retinal capillaries occlusion, occurred in three out of the eleven patients [40]. The severe retinal damage reported in the case of persistent CSC treated with IMP prompted the warning for potential severe adverse events [41].…”

Section: Discussionmentioning

confidence: 99%

Indocyanine green enhanced subthreshold diode-laser micropulse photocoagulation treatment of chronic central serous chorioretinopathy

Ricci

Missiroli

Regine

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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“…In eyes that show diffuse oozing, laser photocoagulation may not be a suitable treatment modality because localization of the leaking point is difficult. Photodynamic therapy (PDT) with verteporfin, which causes less thermal damage, has resulted in beneficial visual outcomes in most studies of patients with chronic CSC [5][6][7]. However, several studies have shown that conventional PDT, traditionally used to treat choroidal neovascularization or polypoidal choroidal vasculopathy, may cause RPE atrophy, choroidal ischemia, and transient reduction in macular function [5,8,9].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Subjects with Chronic Central Serous Chorioretinopathy Undergoing Half-Dose or Time-Reduced Photodynamic Therapy

Kang

2016

J Retin

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Purpose:To compare the clinical outcomes of reduced fluence (time-reduced) photodynamic therapy (PDT) and half-dose PDT in treating chronic central serous chorioretinopathy (CSC). Methods: Medical records of patients who underwent half-dose or reduced fluence PDT for chronic CSC were reviewed. The clinical outcomes of 34 eyes that underwent half-dose PDT and 39 eyes that underwent reduced fluence PDT were compared. Results: Six months after treatment, complete absorption of subretinal fluid was observed in 29 of 34 eyes (85.3%) in the half-dose PDT group and 36 of 39 eyes (92.3%) in the reduced fluence PDT group (p = 0.46). Twenty-one of 34 (61.8%) eyes in the half-dose PDT group and 27 of 39 (69.2%) eyes in the reduced fluence PDT group achieved visual improvement of more than one line in the Snellen chart (p = 0.62). Focal retinal pigment epithelium degeneration after treatment was noted in 7 of 27 eyes (25.9%) in the half-dose PDT group and 10 of 30 (33.3%) eyes in the reduced fluence PDT group (p = 0.58). Conclusions: Reduced fluence PDT showed a favorable outcome, similar to that of half-dose PDT, in treating chronic CSC. Because of its convenient preparation and application, reduced fluence (low-fluence) PDT might be an alternative treatment modality in treating chronic CSC.

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Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy

Cited by 46 publications

References 16 publications

Fundus Autofluorescence before and after Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Fundus Autofluorescence before and after Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Indocyanine green enhanced subthreshold diode-laser micropulse photocoagulation treatment of chronic central serous chorioretinopathy

Comparative Study of Subjects with Chronic Central Serous Chorioretinopathy Undergoing Half-Dose or Time-Reduced Photodynamic Therapy

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