Indocyanine-green videoangiography of drusen as a possible predictive indicator of exudative maculopathy

Hanutsaha, Prut; Dr, Guyer; La, Yannuzzi; Naing, A; Js, Slakter; Js, Sorenson; Rf, Spaide; Freund, K. Bailey; Feinsod, Moshé; Da, Orlock

doi:10.1016/s0161-6420(98)99030-3

Cited by 61 publications

(61 citation statements)

References 14 publications

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“…Ciulla et al 7 also using CDI demonstrated significantly decreased EDV in the central retinal and posterior ciliary arteries in patients with non-exudative ARM, including patients with early ARM (some of which were fellow eyes of unilateral Eye ARM), and patients with geographic atrophy. Because perfusion defects and other circulatory disturbances have been reported in previous studies in fellow eyes of unilateral ARM, [11][12][13] we included patients in the early ARM group in our study if their fellow eye was either normal or had early ARM. The differences in the inclusion criteria impose difficulties in making a valid comparison between the present and the above mentioned studies.…”

Section: (1) Study Of Retrobulbar Circulation In Stages Of Armmentioning

confidence: 99%

“…Choroidal perfusion defects in fellow eyes have been demonstrated using indocyanine-green angiography 12,13 and fluorescein angiography. 11 ERGs of fellow eyes also had slower implicit times than in control age-matched subjects.…”

Section: (1) Study Of Retrobulbar Circulation In Stages Of Armmentioning

confidence: 99%

“…In a fluorescein angiographic study, choroidal perfusion defects were detected in 42% of fellow eyes in unilateral exudative ARM patients and electroretinographic (ERG) abnormalities were also present in those eyes. 11 Indocyanine-green studies reported prolonged choroidal perfusion in 11% 13 and hyperfluorescent areas in 33% of fellow eyes in unilateral exudative ARM. 12 However, the circulation in the fellow eye in unilateral ARM has not been investigated with quantitative methods.…”

Section: Introductionmentioning

confidence: 98%

“…[1][2][3][4] Although the etiology of ARM is not clearly understood, vascular irregularities are present in ARM and a blood circulatory dysfunction has been proposed in the pathogenesis of this disease. [5][6][7][8][9] Because a number of reports [10][11][12][13] have provided qualitative data suggesting abnormalities of the choroidal circulation in ARM, quantitative assessment of the choroidal circulation has been thought to be important for investigating the etiologic role of ocular perfusion in the development of ARM.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, unilateral exudative ARM reportedly has an incidence of progression to exudative ARM in the fellow eye of 3-28% in 1 year 13 and 42% 15 in 5 years. In a fluorescein angiographic study, choroidal perfusion defects were detected in 42% of fellow eyes in unilateral exudative ARM patients and electroretinographic (ERG) abnormalities were also present in those eyes.…”

Section: Introductionmentioning

confidence: 99%

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Retrobulbar circulation in patients with age-related maculopathy

Dimitrova

Tamaki

Kato

2002

Eye

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circulation in patients with age-related maculopathy AbstractPurpose To investigate retrobulbar circulation in stages of age-related maculopathy (ARM) and in normal fellow eyes of patients with unilateral exudative ARM. Methods Color Doppler Imaging was used to measure circulatory parameters (peak-systolic velocity-PSV, end-diastolic velocity-EDV, pulsatility index-PI and resistivity index-RI) in the central retinal, posterior ciliary and ophthalmic arteries of 44 patients with age-related maculopathy (ARM) and 32 control subjects. Patients with ARM consisted of 11 with early ARM and 33 with late ARM. Twenty-one patients from the exudative ARM group were also included in a study of unilateral exudative ARM circulation. Results In the study of patients with ARM divided into stages, the PI and RI in the posterior ciliary artery of patients with late ARM were significantly higher than that of the control group (P ‫؍‬ 0.0064; P ‫؍‬ 0.0124). In the early ARM group, circulatory parameters did not differ significantly from those of the control group.In the study of unilateral exudative ARM, the affected eye showed significantly higher RI, as compared to the control group (P ‫؍‬ 0.0157), and the fellow eye had significantly decreased EDV as compared to the control group (P ‫؍‬ 0.0164). There was no significant difference in circulatory parameters between the affected and normal fellow eyes of patients with unilateral exudative ARM. Conclusion PI and RI in patients with late ARM and EDV in fellow eyes of patients with unilateral exudative ARM showed significant changes in the posterior ciliary artery compared to normal controls. Altered circulation in the posterior ciliary artery may be involved in the pathogenesis of ARM.

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Section: (1) Study Of Retrobulbar Circulation In Stages Of Armmentioning

confidence: 99%

Section: (1) Study Of Retrobulbar Circulation In Stages Of Armmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Retrobulbar circulation in patients with age-related maculopathy

Dimitrova

Tamaki

Kato

2002

Eye

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Incidence of Fellow Eye Involvement in Patients With Unilateral Exudative Age-Related Macular Degeneration

et al. 2018

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Since the advent of optical coherence tomography angiography (OCT-A), nonexudative neovascularization has been described in the fellow eyes of unilateral exudative age-related macular degeneration (AMD). However, there is limited literature describing the natural course and optimal management of these lesions.OBJECTIVE To determine the incidence of fellow eye involvement in patients presenting with unilateral typical AMD or polypoidal choroidal vasculopathy and to evaluate the patterns of OCT-A changes within 6 months before the onset of exudative changes, especially focusing on nonexudative neovascularization. DESIGN, SETTING, AND PARTICIPANTS Data for this study were taken from a prospective, observational cohort study involving Asian patients with exudative AMD in the Asian AMD Phenotyping Study between October 2015 and March 2016. Analyses began in June 2017. Only patients who had gradable OCT-A and indocyanine green angiography (ICGA) scans of the fellow eye at baseline and follow-up at least 6 months apart were included for the analysis. The contralateral eye was evaluated for presence of nonexudative neovascularization based on multimodal imaging, which included ICGA, spectral domain optical coherence tomography, and OCT-A. MAIN OUTCOMES AND MEASURESThe difference between the incidence of those with nonexudative choroidal neovascularization and those without as analyzed using log-rank test and qualitative analysis of OCT-A images. RESULTSWe included 95 fellow eyes of 95 patients who presented with unilateral exudative AMD with a mean (SD) age of 68.6 (8.6) years. Nonexudative neovascularization was present in 18 eyes (19%) (8 [22.9%] and 10 [19.0%] fellow eyes with typical AMD and polypoidal choroidal vasculopathy, respectively; 8 [44.4%] on OCT-A; 5 [27.8%] on ICGA; and 5 [27.8%] on both OCT-A and ICGA). Development of exudative changes was noted in 6 fellow eyes (6.3%). Four eyes developed exudation from previously noted nonexudative neovascularization, and 2 eyes arose exudative changes from de novo. The probability of developing exudation within 6 months was significantly higher in eyes with baseline nonexudative neovascularization (0.087; 95% CI, 0.0033-0.210) compared with eyes without (0.010; 95% CI, 0.0026-0.041) (P=.008). In all eyes whose OCT-A images were available immediately before the onset of exudative changes, there was an increase in the size of network vessels compared with baseline. CONCLUSIONS AND RELEVANCEThe presence of nonexudative neovascularization may predispose to the development of exudative changes.

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Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients With Age-Related Macular Degeneration Treated With Intravitreal Aflibercept or Ranibizumab

et al. 2019

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to neovascular age-related macular degeneration (nAMD) in untreated fellow eyes of patients who are treated for nAMD in 1 eye with anti-vascular endothelial growth factor agents provides important prognostic information to clinically manage patients. OBJECTIVE To investigate the association of treatment assignment (intravitreal aflibercept vs ranibizumab) and baseline characteristics with fellow eye conversion to nAMD in the VEGF (Vascular Endothelial Growth Factor) Trap-Eye: Investigation of Efficacy and Safety in Wet AMD (VIEW) studies. DESIGN, SETTING, AND PARTICIPANTS This post hoc analysis of the VIEW 1 and VIEW 2 studies (randomized, double-masked, active-controlled, multicenter, 96-week, phase 3 trials comparing the efficacy and safety of intravitreal aflibercept in 2457 patients with treatment-naive eyes with nAMD) analyzed a subgroup of participants treated for nAMD in 1 eye who had untreated fellow eyes without neovascularization at baseline. All participants in the VIEW studies were included in 1 of 4 groups: ranibizumab, 0.5 mg, every 4 weeks; aflibercept, 2 mg, every 4 weeks; aflibercept, 0.5 mg, every 4 weeks; or aflibercept, 2 mg, every 8 weeks after 3 injections at 4-week intervals. Data collection in the VIEW studies occurred from July 2007 to August 2011; the data analysis presented in this report took place from April 2016 to November 2018. INTERVENTIONS Patients received no treatment in the fellow eyes unless after conversion to nAMD, when any treatment approved by heath authorities was given per the investigators' discretion. MAIN OUTCOMES AND MEASURES Incidence of conversion to nAMD in patients with untreated fellow eyes that had not had clinical signs of neovascularization at baseline. RESULTS A total of 1561 participants were included in this analysis. At 96 weeks, 375 patients (24.0%) experienced cases of conversion to neovascular disease in the fellow eye, including 107 of the 399 individuals who received ranibizumab, 0.5 mg, every 4 weeks; 93 of the 387 individuals who received aflibercept, 2 mg, every 4 weeks; 84 of the 387 individuals who received aflibercept, 0.5 mg, every 4 weeks; and 91 of the 388 individuals who received aflibercept, 2 mg, every 8 weeks after 3 doses at 4-week intervals. The rates were 18.1, 16.2, 14.7, and 16.0 per 100 patient-years at risk at week 96, respectively. On multivariate analysis, fellow eye conversion was associated with increasing patient age (per 10 years) at baseline (hazard ratio [HR], 1.20 [95% CI, 1.05-1.36]), female sex (HR, 1.32 [95% CI, 1.06-1.63]), intraretinal fluid in the study eye at baseline (HR, 1.28 [95% CI, 1.02-1.61]), and increasing choroidal neovascularization lesion size (per 10 mm 2) in the study eye at baseline (HR, 1.29 [95% CI, 1.06-1.57]). Rates of fellow eye conversion were similar with either of the treatments. CONCLUSIONS AND RELEVANCE In this secondary analysis of randomized clinical trial data, patients with active nAMD in 1 eye appeared to have a high risk for fellow eye conversion. Such patients should be monitored clo...

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Indocyanine-green videoangiography of drusen as a possible predictive indicator of exudative maculopathy

Cited by 61 publications

References 14 publications

Retrobulbar circulation in patients with age-related maculopathy

Retrobulbar circulation in patients with age-related maculopathy

Incidence of Fellow Eye Involvement in Patients With Unilateral Exudative Age-Related Macular Degeneration

Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients With Age-Related Macular Degeneration Treated With Intravitreal Aflibercept or Ranibizumab

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