Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors

Passos, Carolina S.; Simões-Pires, Cláudia A.; Nurisso, Alessandra; Soldi, Tatiane Cristina; Kato, Lucília; Oliveira, Cecília Maria Alves de; Faria, Emiret O.; Marcourt, Laurence; Gottfried, Carmem; Carrupt, Pierre‐Alain; Henriques, Amélia T.

doi:10.1016/j.phytochem.2012.11.015

Cited by 79 publications

(78 citation statements)

References 47 publications

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“…Compounds 1-3 exhibited moderate activity compared to the positive control galanthamine. The AChE inhibitory activity of compound 1 is in accordance with that of other b-carbolines described in the literature (Passos et al, 2013).…”

Section: Resultssupporting

confidence: 87%

Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Queiroz

Zeraik

et al. 2014

Phytochemistry Letters

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Section: Resultssupporting

confidence: 87%

Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Queiroz

Zeraik

et al. 2014

Phytochemistry Letters

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“…59 The monoterpene indole alkaloids lyaloside (26) and strictosamide (22) exhibited inhibitory effect on MAO-A (IC 50 50.04 and 132.5 μg mL -1 , respectively) and MAO-B (IC 50 306.6 and 162.8 μg mL -1 , respectively). 59,60,84 These data confirm the previous study made by McKenna et al 5 which also demonstrated inhibition of MAO by alkaloids compounds present in hallucinogenic "ayahuasca" drink.…”

Section: Neurodegenerative Diseasessupporting

confidence: 85%

“…Recently, several Psychotria alkaloids, mainly monoterpene indoles and β-carboline alkaloids have been reported for their inhibitory properties against acetylcholinesterase and monoamine oxidase proteins, which are enzymatic targets related with neurodegenerative diseases. 60,102 Alkaloidal fractions of Psychotria suterella and Psychotria laciniata as well as two monoterpene indole alkaloids isolated from these fractions were evaluated against monoamine oxidases (MAO-A and MAO-B) obtained from rat brain mitochondria. 59 The monoterpene indole alkaloids lyaloside (26) and strictosamide (22) exhibited inhibitory effect on MAO-A (IC 50 50.04 and 132.5 μg mL -1 , respectively) and MAO-B (IC 50 306.6 and 162.8 μg mL -1 , respectively).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

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The GenusPsychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties

Calixto¹,

Pinto²,

Ramalho³

et al. 2016

Journal of the Brazilian Chemical Society

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Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately 1600 species. The available references demonstrate that Psychotria has several uses on traditional medicine including spiritual and cultural purposes, and presents great potential on pharmacological properties, especially the one related to neurodegenerative diseases. Despite its wide biological properties, this genus has shown complex phylogenetic analysis due to lack of chemotaxonomic information. In recent years, the interest in these plants has increased considerably and many active compounds have been isolated. Phytochemical investigations described in the literature confirmed the indole alkaloids as the major compounds and besides that, another particular chemical constituent are cyclic peptides, known as cyclotides. This present review will cover the relevant literature from 1962 until 2015, and outlines the current data on taxonomy, chemotaxonomy, traditional uses, pharmacological properties, chemical composition and ecological approach from Psychotria genus.

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“…It has therefore become imperative to develop multidimensional thera peutic approach at the prevention and management of these diseases by focusing attention on these key etiological factors. In this regard, cho linesterase and monoamine oxidase inhibitors, as well as antioxidant therapy, have been the focus of drug design [1,2]; nevertheless, the im portance of dietary interventions as complementary approach at pre vention and management of these diseases cannot be overemphasized.…”

Section: Introductionmentioning

confidence: 99%

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

et al. 2016

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Green leafy vegetable is one of the major cuisines in Southern Nigeria and they are not only consumed for their palatability, but also for their nutritional and medicinal properties as reported in folklore. Notable among them are afang (Gnetum africanum), editan (Lasianthera africana) and utazi (Gongronema latifolium). In this study, we investigated the effect of aqueous extracts from afang, editan and utazi leaves on cholinesterases [acetylcho linesterase (AChE) and butyrylcholinesterase (BChE)] and monoamine oxidase (MAO) activities. Fe 2+ chelating abilities were also determined as an assessment of their neuroprotective potentials in vitro. We also assayed for their total phenol contents while the constituent phenolics were characterized using high performance liquid chromatography coupled with diode array detector (HPLC-DAD). The results revealed that the extracts inhibited AChE, BChE and MAO activities and also chelated Fe 2+ in concentration dependent manner. The HPLC-DAD char acterization showed that gallic, caffeic and ellagic acids and rutin were the dominant phenolic compounds in the extracts; nevertheless, utazi had the highest distribution of identified phenolics while afang had the least. The ability of the aqueous extracts of the vegetables to inhibit key enzymes (AChE, BChE and MAO) relevant to neu rodegeneration, as well chelate metal ion could help suggest their possible neuroprotective properties. These vegetables could be use as dietary intervention in the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.

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Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors

Cited by 79 publications

References 47 publications

Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

The GenusPsychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

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