“…One potential use for this family of compounds could be in targeting transporters to acidic cellular organelles such as lysosomes. We have also explored the possibility of tuning the pKa of a protonatable nitrogen atom in the perenosins, 28,29 and probed the effect subtle differences in the pH environment have on the chloride transport abilities. Here, the Cl -/NO3exchange ISE assay was run at Chloride, bicarbonate and phosphate are the most abundant anions in the body, 8 but other anions, such as fluoride, 36 sulfate 37 and nitrate, 38 and cations, such as sodium, potassium, magnesium and calcium, 39 are biologically relevant.…”