Indole-incorporated-benzoeindolium as a novel mitochondrial and ratiometric fluorescent probe for real-time tracking of SO2 derivatives in vivo and herb samples

Small-molecule fluorogenic probes based on indole scaffold

“…In 2021, Yuyu Fang and co-workers designed an indole-incorporated-benzoeindolium ratiometric fluorescent probe 13 for the detection of SO 2 derivatives. 51 The probe 13 was made by the reaction between 3-ethyl-1,1,2-trimethyl-1- H -benzo[ e ]indole-3-ium iodide and 6-methyl-1 H -indole-3-carbaldehyde in ethanol. The probe in DMSO/H 2 O (2 : 3 v/v, pH = 7.4) revealed two absorption bands at 489 nm and 300 nm but in the presence of SO 2 derivative (HSO 3 − and SO 3 2− ) the absorption band at 489 nm disappeared and two new peaks were observed at 270 nm and 325 nm, with colour change from faded red to colourless.…”

Research Progress of Sulfur Dioxide Fluorescent Probe Targeting Mitochondria

“…该探针在加入 2021 年, 张书胜课题组 [38] 设计并合成了首个具有 聚集诱导发光增强特性的近红外荧光探针 15, 由 3H-苯 并[f]吡喃-2-甲醛与吲哚阳离子缩合而成, 用于 SO 2 衍生 物在体外、细胞和斑马鱼中的比率型检测. 在该探针中 加入 2022 年, 邓赟课题组 [40] 基于 ICT 机理, 由甲基吲哚 为供体、苯并吲哚为受体设计并合成了探针 17, 用于检 测中药的 SO 2 衍生物. 在该探针中加入 5 equiv.的 2019 年, 冯燕课题组 [46] 报道了一例基于 ICT 机理, 由苯并噻唑衍生物与咔唑构建而成靶向线粒体比率荧 光探针 22.…”

A near-infrared fluorescent probe for in situ imaging of SO2 flux in drug-induced liver injury

“…2 It plays an important regulatory role in many physiological and pathological processes to maintain homeostasis. [3][4][5] In particular, studies have shown that SO 2 may play a crucial role in combating redox disturbances caused by liver damage. 6,7 However, its regulatory mechanism during disease remains to be elucidated.…”