Indolent Stage IE Non-Hodgkin’s Lymphoma of the Orbit: Results after Primary Radiotherapy

Abstract

Aims: Primary non-Hodgkin’s lymphoma (NHL) of the orbit is uncommon, representing approximately 8% of extranodal NHLs. Twenty-two patients with indolent stage IE NHL were reviewed retrospectively to analyze the outcome and late effects of primary local radiotherapy. Materials and Methods: The median age at first diagnosis was 63.5 years (range 24–82 years). Extranodal mucosa-associated lymphoid tissue lymphoma (n = 15) was the most common histological subtype of NHL, followed by follicular (n = 6) and lymphoplasmacytic lymphoma (n = 1). Radiotherapy was performed using a linear accelerator. The median radiation dose was 40 Gy (range 30–46 Gy). None of the patients received chemotherapy before irradiation. The follow-up period was 62 months (range 8–136 months). Results:A complete response was achieved in all patients. The 5-year local control rate was 100%. Distant relapse occurred in 2 patients, resulting in a 5-year distant relapse-free survival rate of 88%. The 5-year overall survival rate was 89%; there were no lymphoma-related deaths. No serious acute complications (grade 3/4) were observed. Grade 1/2 late effects were documented in 44% of patients. Grade 3 complications (cataract: 2, dryness: 2) were observed in 4 patients (18%). Conclusions: Indolent early stage orbital NHL can be controlled with local radiotherapy. Morbidity is low. Regular follow-up examinations are necessary to detect rare cases of distant relapse.

Primary, Unilateral Ocular Adnexal Lymphoma: Disease Progression and Long-Term Survival

“…[12][13][14][15] For patients with aggressive lymphoma (diffuse large B-cell lymphoma, immunoblastic lymphoma, mantle cell lymphoma, and unclassifiable large cell lymphoma) patients also received multiagent chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone or a close equivalent. [12][13][14][15] For patients with aggressive lymphoma (diffuse large B-cell lymphoma, immunoblastic lymphoma, mantle cell lymphoma, and unclassifiable large cell lymphoma) patients also received multiagent chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone or a close equivalent.…”

Evolution of Care of Orbital Tumors with Radiation Therapy

“…Observation, surgery, antibiotics, steroids, radiation therapy, chemotherapy, and immunotherapy have been recommended as a treatment strategy for these neoplasms. [59][60][61][62][63] External beam radiotherapy (EBRT) is the primary treatment of choice for localized, low-grade lymphomas. Target volume usually includes the entire orbit for patients with any intraorbital involvement, while for superficial small lesions confined to the conjunctiva or the eyelid, target volume includes only the tumor plus a small margin (►Fig.…”

LIMFOMA MALIGNA PADA MATA YANG DIRAWAT DI RUMAH SAKIT Dr. M. DJAMIL PADANG TAHUN 2003-2010

“…(2, 19) Pada penelitian ini, semua pasien dianjurkan untuk kemoterapi, namun hanya 10 pasien yang menjalaninya. Sisanya menolak untuk dilakukan kemoterapi, sebagian besar dengan alasan ekonomi.…”