Indolent triple negative breast cancer

Abstract

Triple-negative breast cancer (TNBC), while not the most frequent subtype, has a surprisingly aggressive course and low sensitivity to current antitumour drugs. Detection of predictive BRCA-mutation and administration of targeted therapy in the first lines of treatment of metastatic TNRML can significantly affect the life expectancy of patients. The clinical case of patient O. with BRCA-associated bilateral metachronous metastatic breast cancer demonstrates how important it is to implement a personalised approach in time. During the patient’s treatment, it was important to constantly compare the initial morphological profile of the tumour and the clinical course of the disease in order to suspect a discrepancy and to revise the surgical material. The administration of systemic drug therapy, taking into account the genetic and immunohistochemical features of the tumour, made it possible to achieve prolonged recurrence-free periods in two consecutive lines of treatment with preservation of the patient’s decent quality of life.