Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells

Guo, Xingchen; Fan, Aili; Qi, Xinyi; Liu, Dong; Huang, Jian; Lin, Wenhan

doi:10.1016/j.bioorg.2023.106873

Cited by 6 publications

(1 citation statement)

References 61 publications

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“…Since then, more and more novel bioactive natural products have been continuously isolated from marine-derived Aspergillus species, including p -terphenyl derivatives of asperterphenyls A-N from A. sp. SCSIO41315 [ 6 ], cyclopentapeptides of pseudoviridinutans A-F from A. pseudoviridinutans TW58-5 [ 7 ], and indoloquinazoline alkaloids of clavutoines A-U from A. clavutus LZD32-24 [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Sun,

Ha,

Liu

et al. 2024

Molecules

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Fungi are important resource for the discovery of novel bioactive natural products. This study investigated the metabolites produced by Mariana-Trench-associated fungus Aspergillus sp. SY2601 in EY liquid and rice solid media, resulting in the isolation and structure determination of 28 metabolites, including five new compounds, asperindopiperazines A–C (1–3), 5-methoxy-8,9-dihydroxy-8,9-deoxyaspyrone (21), and 12S-aspertetranone D (26). Structures of the new compounds were elucidated based on extensive NMR spectral analyses, HRESIMS data, optical rotation, ECD, and 13C NMR calculations. The new compound 12S-aspertetranone D (26) exhibited antibacterial activity against both methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 3.75 and 5 μg/mL, respectively.

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Section: Introductionmentioning

confidence: 99%

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Sun,

Ha,

Liu

et al. 2024

Molecules

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Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

Azevedo,

Ferreira,

Peña‐Corona

et al. 2024

Food Frontiers

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Angiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product‐based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natural compounds, including polyphenols, terpenes, alkaloids, cannabinoids, omega‐3 fatty acids, polysaccharides, proteins, and carotenoids, were investigated for their antiangiogenic properties. Challenges such as dose standardization, routes of administration, and potential side effects remain. Further studies, including in‐depth animal models and human epidemiological studies, must elucidate clinical efficacy and safety. Synergistic effects with current antiangiogenic therapies, such as bevacizumab and tyrosine kinase inhibitors, should be explored. Additionally, the potential hormone‐dependent effects of compounds like genistein highlight the need for safety evaluation. In conclusion, natural products hold promise as adjunctive therapies to conventional antineoplastic drugs in modulating angiogenesis in cancer. However, robust clinical trials are needed to validate preclinical findings and ensure safety and efficacy.

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Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy

Jiang,

Zhang,

Zhang

et al. 2024

Seminars in Cancer Biology

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Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells

Cited by 6 publications

References 61 publications

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy

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