“…The synthesis of the 6-fluoroindole-substituted target compounds with alkyl spacer between carbamate group and indole heterocycle (9,11,13,15) were obtained by reaction of the appropriate indolyl-substituted alkan-1-amines (8, 10, 12, 14) [23,24] with an activated carbonate formed from 1,1,1,3,3,3hexafluoropropan-2-ol and bis(pentafluorophenyl) carbonate in acetonitrile in presence of triethylamine (Scheme 1). [18] For the synthesis of the indol-1-ylalkyl-substituted piperidine carbamates 20, 24, 28 and 32, 6-fluoroindole was Nalkylated with the corresponding 4-(mesyloxyalkyl)piperidine protected as its benzyloxycarbonyl derivative (17, 21, 25, 29) [25] using sodium hydride as base (Scheme 2).…”