Indomethacin‐Associated Hyperkalemia in the Elderly

Meier, Diane E.; Myers, W. Michael; Swenson, Robert; Bennet, W. M.

doi:10.1111/j.1532-5415.1983.tb05749.x

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…54 The physician should assume that the geriatric patient will have some impairment of renal clearance of an NSAID on the basis of aging alone, which will increase the potential for an NSAID-associated adverse effect. 54,60 A serum creatinine concentration greater than 1.2 mg/dL, congestive heart failure, or concurrent therapy with a diuretic will increase the potential for toxicity even more. [60][61][62][63][64][65][66]…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Hyperkalemia in the elderly

1997

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Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Hyperkalemia in the elderly

1997

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“…The resulting decrement in renal blood flow and the decrease in the RAAS activity can explain the serum potassium increasing from a pretreatment concentration of 4.5 mEq/L to 5.0 mEq/L [17,18]. NSAIDs produce analgesia relatively sooner than their ability to exert an antiinflammatory effect.…”

Section: -Age X Body Wt (Kg)mentioning

confidence: 99%

Clinical Pharmacology - Physiology Conference

Löwenthal

1994

Geriatric Nephrol Urol

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“…Hyporeninemic hypoaldosteronism with hyperkalemia usually involves elderly patients with CHF, diabetes mellitus, chronic renal insufficiency, hypertension, infection, or gout. Acute illness or stress apparently are not predisposing factors, but use of potassium‐sparing diuretics and potassium supplements is 57,58 . The use of potassium‐sparing diuretics in the elderly is increasing.…”

Section: Potential Renal Effects Of Nsaidmentioning

confidence: 99%

Renal Effects of Nonsteroidal Antiinflammatory Drugs

Lamy

1986

J American Geriatrics Society

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America's population is aging, and there is a direct relationship between advancing age and sensitivity to adverse drug reactions (ADRs). The number of the old old, those 85 years and older, will increase by 114% by the year 2000, and by another 44% in the subsequent 20 years.1 The largest absolute and relative increases are seen and will continue to be seen for unmarried women older than 85 years (women are more sensitive to ADRs than are men). Importantly, the population 95 years of age and older has increased by about twice the rate of the aggregate population 85 years and older. Activity limitations among community‐living elderly rise precipitously with age, afflicting about 12% of those 65 to 74 years old but almost 46% of those 85 years and older.2 It has been estimated that approximately 4.6 million community‐living elderly are limited in activities of daily living (ADLs) or instrumental activities of daily living (IADLs, cognitive impairment),3 and that number may double, triple, or even quadruple in the next 50 years.

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Indomethacin‐Associated Hyperkalemia in the Elderly

Cited by 10 publications

References 20 publications

Hyperkalemia in the elderly

Hyperkalemia in the elderly

Clinical Pharmacology - Physiology Conference

Renal Effects of Nonsteroidal Antiinflammatory Drugs

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