1976
DOI: 10.1002/ijc.2910180514
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Indomethacin enhancement of spleen‐cell responsiveness to mitogen stimulation in tumorous mice

Abstract: Spleen cells removed from C57Bl/6J mice bearing a methylcholanthrene-induced fibrosarcoma (MC-16) demonstrate suppressed responsiveness of phytohemagglutinin (PHA) and bacterial lipopolysaccharide (LPS) induced mitogenesis as compared to non-tumorous mice. A similar depression of PHA-induced mitogenesis was observed with spleen cells from C3H/HeJ mice bearing syngeneic mammary adenocarcinomas (C3HBA). The administration of indomethacin, a non-competitive irreversible prostaglandin (Pg) synthesis inhibitor, (75… Show more

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Cited by 63 publications
(17 citation statements)
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“…As for the tumour systems described by Pelus & Strausser (1976) and Goodwin et al (1977) the PHA response of lymphocytes from animals bearing McC3-I tumours was markedly lower than normal. This was not simply due to a dilution of the mitogen-sensitive cells in the greatly hyperplastic spleens, as such cells also suppressed the proliferative response of normal spleen cells.…”
Section: Effect Of Tumour-and Indomethacin On Antibody Synthesismentioning
confidence: 86%
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“…As for the tumour systems described by Pelus & Strausser (1976) and Goodwin et al (1977) the PHA response of lymphocytes from animals bearing McC3-I tumours was markedly lower than normal. This was not simply due to a dilution of the mitogen-sensitive cells in the greatly hyperplastic spleens, as such cells also suppressed the proliferative response of normal spleen cells.…”
Section: Effect Of Tumour-and Indomethacin On Antibody Synthesismentioning
confidence: 86%
“…It has been suggested that the immunosuppression described in some tumour-bearing animals results from the influence of these hormones on the immune system. Aspirin and indomethacin may, therefore, restore the immune function by inhibiting their synthesis (Plescia et al, 1975;Strausser & Humes, 1975;Pelus & Strausser, 1976) and thus augmenting the anti-tumour immune responses. This attractive hypothesis is not, however, necessarily supported by our results with the McC3-I tumour.…”
Section: Effect Of Tumour-and Indomethacin On Antibody Synthesismentioning
confidence: 99%
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“…Effects of PGE on in vitro tumour growth are disputed, either enhancing by decreasing immune surveillance [11,12] or inhibiting [14,16]. Ifit is likely that prostaglandins E have a function in the growth of human tumours, yet little is known about the biological significance of PGs in cancer and, more particularly, in malignant lymphomas.…”
Section: Discussionmentioning
confidence: 99%
“…In creased production of PGE2 has been ob served in a variety of tumour cell lines de rived from carcinogen-induced neoplasms in rats when these cells were exposed to puri fied lymphocytes from peripheral blood or spleen of the same rat line [43]. It is likely that this increased PGE2 production plays a role in immunosuppression by tumour cells in that PGE2 itself is immunosuppressive and that inhibitors of prostaglandin synthe tase such as aspirin and indomethacin block immunosuppression in vitro and retard tu mour growth in vivo [44], Administration of indomethacin is capable of causing an enhancement of immune responsiveness in tumour-bearing mice [45], This suggests that tumours or tumour-cell antigens increase prostaglandin production in a population of spleen cells which in turn decrease immune responsiveness.…”
Section: Prostaglandins and The Immune Responsementioning
confidence: 99%