Indomethacin Increases the Efficacy of Oxygen Utilization of Colonic Mitochondria and Uncouples Hepatic Mitochondria in Tissue Homogenates From Healthy Rats

Herminghaus, Anna; Buitenhuis, Albert J; Schulz, Jan; Truse, Richard; Vollmer, Christian; Relja, Borna; Bauer, Inge; Picker, O.

doi:10.3389/fmed.2020.00463

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…In addition, Truse et al [87] also proved that melatonin could significantly regulate gastric microcirculatory oxygenation, which may be a new aspect of the protective effect. Herminghaus et al [88] found that indomethacin significantly affects mitochondrial function in healthy rats, which is organ-specific and concentrationdependent, and its effect should be further confirmed by in vivo studies. A recent study found that mitochondrial transplantation may be valuable in restoring organ function to critically ill patients [89].…”

Section: Mitochondria-guided Treatmentsmentioning

confidence: 95%

Microcirculation and Mitochondria: The Critical Unit

Wang,

Lian,

Zhang

et al. 2023

JCM

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Critical illness is often accompanied by a hemodynamic imbalance between macrocirculation and microcirculation, as well as mitochondrial dysfunction. Microcirculatory disorders lead to abnormalities in the supply of oxygen to tissue cells, while mitochondrial dysfunction leads to abnormal energy metabolism and impaired tissue oxygen utilization, making these conditions important pathogenic factors of critical illness. At the same time, there is a close relationship between the microcirculation and mitochondria. We introduce here the concept of a “critical unit”, with two core components: microcirculation, which mainly comprises the microvascular network and endothelial cells, especially the endothelial glycocalyx; and mitochondria, which are mainly involved in energy metabolism but perform other non-negligible functions. This review also introduces several techniques and devices that can be utilized for the real-time synchronous monitoring of the microcirculation and mitochondria, and thus critical unit monitoring. Finally, we put forward the concepts and strategies of critical unit-guided treatment.

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Section: Mitochondria-guided Treatmentsmentioning

confidence: 95%