Indomethacin solubilization induced shape transition in CnE7 () nonionic micelles

Complex Fluids of Poly(oxyethylene) Monoalkyl Ether Nonionic Surfactants

“…The ultimate formation of wormlike micelles with a cross-sectional diameter of 2.4 nm was also obtained in the C 14 EO 6 system at 40 °C, and they varied from 50 nm to several hundreds of nanometers in length with the surfactant concentration approaching the phase boundaries. 79 A similar effect of the temperature on the apparent micelle size or shape was obtained in C 12 EO 4 , 94 C 12 EO 23 , 95,96 C 17 EO 84 , 97 C 14 EO 7 , 41,98 and C 16 EO 7 99,100 aqueous solutions.…”

“…23,68,71 A number of technologies have been mutually used to accurately monitor micelle growth with temperature. The techniques include self-diffusion NMR, [71][72][73][74] smallangle neutron scattering (SANS), [75][76][77][78] light scattering, 41,[79][80][81] and cryogenic transmission electron microscopy (cryo-TEM). 82,83 In addition, the cmc of C n EO m solutions will decrease markedly with increasing temperature below the cloud point, 23 because increasing the temperature weakens the hydration of the EO headgroups, which favors micellization.…”

“…In dilute C n EO m surfactant solutions, micelles grow and change shape with increasing temperature, but well below the cloud point, as a result of interactions between the micelles and water, and especially as the cloud point is approached. ,, A number of technologies have been mutually used to accurately monitor micelle growth with temperature. The techniques include self-diffusion NMR, − small-angle neutron scattering (SANS), − light scattering, ,− and cryogenic transmission electron microscopy (cryo-TEM). , In addition, the cmc of C n EO m solutions will decrease markedly with increasing temperature below the cloud point, because increasing the temperature weakens the hydration of the EO headgroups, which favors micellization. This is the predominant driving force for the decrease in cmc, even though repulsive interactions between water and the alkyl chains simultaneously become weaker at high temperature, which is unfavorable for micelle formation.…”

Peculiar Mechanism of Solubilization of a Sparingly Water Soluble Drug into Polymeric Micelles. Kinetic and Equilibrium Studies

“…However, in any case, the application of polymeric micelles as drug delivery systems of sparingly soluble substances cannot leave out of consideration the wide and in-depth study of the drug–water solubilization. To date, most of the studies have dealt with aspects of solubilization under equilibrium conditions − whereas little attention, because of appreciable experimental difficulties, has been paid to the kinetics of the solubilization process. A knowledge of the kinetics of the solubilization process is very important particularly in areas such as drug delivery and carrying.…”

Solubilization of n-alkylbenzene and n-perfluoroalkylbenzene in hydrogenated and fluorinated surfactants micelles

“…Further, light scattering and transmission electron microscopy (TEM) observations [15,22] confirm that TTAC forms spherical micelles [21], while C10F-TAC forms disk-like aggregates. The size and structure of aggregates change with the solubilizing concentration [16,23]. However, the main purpose of this study is to measure the solubilities of n-alkylbenzene and n-perfluoroalkylbenzene in hydrogenated and fluorinated surfactants.…”