Indomethacin Treatment of Acute Pancreatitis: A Controlled Double-Blind Trial

Abstract

Thirty patients with acute pancreatitis were allocated to indomethacin suppositories, 50 mg twice daily, or identical-looking placebo suppositories for 7 days in a controlled double-blind trial. The groups of patients were not different with regard to age, sex, etiology, or number of Ranson criteria. The number of days with pain and number of opiate injections were significantly less in patients treated with indomethacin. The median values of serum amylase and serum calcium were not different before or at any day during treatment. Bleeding from the gastrointestinal tract was not seen.

Efecto de la administración de indometacina rectal sobre los niveles séricos de amilasa posteriores a colangiopancreatografía retrógrada endoscópica y su impacto en la aparición de episodios de pancreatitis secundaria

“…La inhibición de FLA2 ha sido el objetivo de varios agentes terapéuticos usados para tratar pancreatitis aguda no inducida por CPRE con resultados decepcionantes. En estudios previos sólo el mesilato de gabexato ha demostrado prevenir el daño pancreático relacionado con la CPRE y reduce la incidencia (30).…”

Significance of thromboxane A2 and prostaglandin I2 in acute necrotizing pancreatitis in rats

“…Other prostanoid mediators may play a more or less significant role as well (6). When prostaglandin synthesis is completely blocked by indomethacin (1 mg/kg), the course of ANP is not ameliorated at all (5), although no agreement exists (18)(19)(20).…”

Treatment of Acute Pancreatitis: An Attempted Historical Review

“…In the 1970s, oral or intramuscular administration of indomethacin before or shortly after the triggering of an acute pancreatitis attack in rats markedly reduced mortality [90]. Several years later, in a controlled double-blind study, a Danish group achieved a clear reduction in the frequency and intensity of pain in patients with acute pancreatitis by administering indomethacin suppositories 50 mg twice daily for 7 days [91]. …”