Indonesian Sargassum species bioprospecting: potential applications of bioactive compounds and challenge for sustainable development

Puspita, Maya; Setyawidati, Nur Azmi Ratna; Stiger‐Pouvreau, Valérie; Vandanjon, Laurent; Widowati, Ita; Radjasa, Ocky Karna; Bedoux, Gilles; Bourgougnon, Nathalie

doi:10.1016/bs.abr.2019.12.002

Cited by 25 publications

(20 citation statements)

References 171 publications

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“…Polysaccharides in the cell walls of all brown algae, including Sargassum species (which include pelagic sargasso and benthic species) prevent the algae from drying out and also provide strength and flexibility (Puspita et al, 2020). The most abundant polysaccharide in sargasso is alginate (Liu et al, 2012), which has applications in the pharmaceutical and food industries, where they are used as thickeners and stabilizers; their viscous consistency is due to their water absorption capacity (Jesumani et al, 2019).…”

Section: Alginates and Fucoidansmentioning

confidence: 99%

“…At present, in Mexico, phenolic compounds are not extracted from sargasso for commercialization, but this may be possible in a biorefinery. Phenolic compounds have been reported in various species of Sargassum (Puspita et al, 2020), whereas Davis et al (2020) determined the content of phenolic compounds in sargasso (S. natans and S. fluitans), using the methodology of Folin-Ciocalteu. They found that S. natans contained up to 3.10 mg/g of dry biomass and S. fluitans 1.20 mg/g of dry biomass.…”

Section: Products Of High Added-valuementioning

confidence: 99%

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Commercial Potential of Pelagic Sargassum spp. in Mexico

et al. 2021

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The recent periodic influx of massive quantities of pelagic Sargassum spp. (sargasso) into the Caribbean has posed ecological, social, and economic challenges to the region. Sustainable use of the biomass is crucial to mitigate negative impacts of beached algae. The current uses of sargasso in Mexico are reviewed, and a biorefinery approach is proposed to optimize its commercialization. The commercialization potential of sargasso in the Mexican Caribbean is analyzed using the strengths, weaknesses, opportunities, and threats (SWOT) analysis. The unpredictability of the influx to the Mexican shores is considerable, both in time and space, also, some areas receive consistently more sargasso than others. The lack of available technology, local infrastructure and regulations concerning sargasso are relevant, as is the urgent need to establish proper regulatory measures. In the context of the Mexican legal system, the category “special waste” can best be applied to sargasso that is collected from the beach or nearshore waters for the purpose of regulation. Lessons learnt from in Mexico may be applied elsewhere, with adaptations for each specific location. More importantly, mutual understanding of the constraints and possibilities of sargasso management in other countries, or territories, may facilitate the coordinated management of this transboundary macroalgae bloom.

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Section: Alginates and Fucoidansmentioning

confidence: 99%

Section: Products Of High Added-valuementioning

confidence: 99%

Commercial Potential of Pelagic Sargassum spp. in Mexico

et al. 2021

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“…The use of Eucheuma sp. as a source of L-asparaginase must of course be limited to a certain amount so that its presence in nature is not reduced and causes disruption of ecosystems in Indonesian water (Puspita et al, 2020) . Hence, the use of endophytic microorganisms is of concern.…”

Section: Introductionmentioning

confidence: 99%

“…Biodiversity of Indonesian water provides wide opportunities to utilize marine resources as a search for new bioactive compounds (Puspita et al., 2020). Coastal Indonesia produces macroalgae in abundance (Bleakley & Hayes, 2017; Puspita et al., 2020). Eucheuma sp.…”

Section: Introductionmentioning

confidence: 99%

A novel L‐asparaginase from the symbiotic Enterobacter aerogenes isolated from Eucheuma sp.

Masri

Nur

Widodo³

et al. 2022

Food Processing Preservation

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This study was aimed to purify and characterize the enzyme L-asparaginase from endophytic microorganisms of Eucheuma sp. in Puntondo Island, South Sulawesi, Indonesia. Research stages were ammonium sulfate precipitation, dialysis, and Sephadex G-75 gel filtration chromatography and Sephadex CMC-50 ion-exchange chromatography matrices. The result of test activities of ammonium sulfate fraction showed the highest range of 40%-60% the activity value of 6.71 IU/ml. The highest protein content was obtained on a 0%-20% fraction of 2.76 mg/ml. Temperature and pH assessments indicated that L-asparaginase had optimum activity at 37°C and pH 8, respectively. At the stage of dialysis, the highest protein content was 5.17 IU/ml in a 0%-20% fraction, and the highest enzyme activity was 1.23 IU/ml in a 20%-40% fraction. The results of gel filtration chromatography fractions G-75 were F5-F10, with a specific activity of 0.60 U/mg, 2.05 times higher purity level than the crude extract enzyme. The results of CMC-50 ion-exchange chromatography showed that F54 and F55 fractions had a specific activity of 106.97 and 295.38 U/mg, respectively, with a purity level of 366.34 and 1,011.57 times higher than the crude extract enzyme. Novelty impact statementEnterobacter aerogenes strain P5, an endophytic bacterium from Eucheuma sp., can produce pure L-asparaginase enzyme with a high specific activity applied in pharmaceuticals nutraceutical applications.

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“…Sargassum sp. is a type of seaweed that is spread in Indonesia (6,7) . Brown seaweed contains bioactive compounds such as fucoidan, phloroglucinol and fucoxanthin.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review

Ismylatifa Devi,

Diah Purwaningsari,

Nita Pranitasari

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Breast cancer was one of the most common types of cancer in women and the major cause of death. Chemotherapy in breast cancer caused toxicity to the normal cells, resistance to the drugs, and several other side effects. Seaweed had many functional compounds that could be used as adjuvant therapy in breast cancer because of its anti-cancer properties called the proapoptotic agent. These compounds were fucoidan, phloroglucinol, and fucoxanthin. Their proapoptotic mechanisms shown by the journal were through increasing proapoptotic protein expression, decreasing antiapoptotic protein expression, inducing oxidative stress production on the cancer cell, and inhibiting the PI3K pathway. This review concludes that the brown seaweed (Sargassum sp.), which contains fucoidan, phloroglucinol, and fucoxanthin, could increase breast cancer cells' apoptotic process.

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Indonesian Sargassum species bioprospecting: potential applications of bioactive compounds and challenge for sustainable development

Cited by 25 publications

References 171 publications

Commercial Potential of Pelagic Sargassum spp. in Mexico

Commercial Potential of Pelagic Sargassum spp. in Mexico

A novel L‐asparaginase from the symbiotic Enterobacter aerogenes isolated from Eucheuma sp.

The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review

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