Indoor air microbial load, antibiotic susceptibility profiles of bacteria, and associated factors in different wards of Arba Minch General Hospital, southern Ethiopia

Kayta, Gebre; Manilal, Aseer; Tadesse, Dagimawie; Siraj, Munira

doi:10.1371/journal.pone.0271022

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…2018 [ 39 ] South Ethiopia Feb. to April,2021 2022 CS 120 Hospital Indoor air samples Phenotypic 120 Kayta G, et al . 2022 [ 40 ] South Ethiopia May to June, 2018 2021 CS 99 Swab samples from hospital contact surfaces Phenotypic 71 Birru M, et al . 2018 [ 41 ] South Ethiopia Nov 2014 to Feb,2015 2016 CS 120 Hospital Indoor air samples Phenotypic 120 Hailemariam M, et al .…”

Section: Resultsmentioning

confidence: 99%

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Abayneh,

Zeynudin,

Tamrat

et al. 2023

One Health Outlook

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Background Although antimicrobial resistance (AMR) bacteria present a significant and ongoing public health challenge, its magnitude remains poorly understood, especially in many parts of the developing countries. Hence, this review was conducted to describe the current pooled prevalence of drug resistance, multidrug- resistance (MDR), and Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Acinetobacter, and Pseudomonas species in humans, the environment, and animals or food of animal origin in Ethiopia. Methods PubMed, Google Scholar, and other sources were searched for relevant articles as per the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. A critical appraisal for screening, eligibility, and inclusion in the meta-analysis was made based on the Joanna Briggs Institute’s (JBI) essential appraisal tools. The meta-analysis was done on Statistical Software Package (STATA) version 17.0. Results A total of 33 research articles were included in this systematic review and meta-analysis. Escherichia coli, Klebsiella species, Acinetobacter, and Pseudomonas species were the most frequently reported bacteria from two or more sources. More than 50% of Klebsiella species and 25% to 89% of Escherichia coli from two or more sources were resistant to all analysed antibiotics, except carbapenems. Fifty-five percent (55%) to 84% of Acinetobacter species and 33% to 79% of Pseudomonas species from human and environmental sources were resistant to all analyzed antibiotics. Carbapenem resistance was common in Acinetobacter and Pseudomonas species (38% to 64%) but uncommon in Enterobacteriaceae (19% to 44%). Acinetobacter species (92%), Klebsiella species (86%), and Pseudomonas species (79%) from human sources, and Proteus species (92%), and Acinetobacter species (83%), from environmental sources, were the common multidrug-resistant isolates. About 45% to 67% of E. coli, Klebsiella, Acinetobacter, and Pseudomonas species from human and environmental sources were ESBL producers. Conclusion Our review report concluded that there was a significant pooled prevalence of drug resistance, MDR, and ESBL-producing Enterobacteriaceae, Acinetobacter, and Pseudomonas species from two or more sources. Hence, our finding underlines the need for the implementation of integrated intervention approaches to address the gaps in reducing the emergence and spread of antibiotic- resistant bacteria.

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Section: Resultsmentioning

confidence: 99%

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Abayneh,

Zeynudin,

Tamrat

et al. 2023

One Health Outlook

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“…In addition to human colonization, MDROs (including CPE) can also be spread by contaminated surfaces; hands [184]; money [185]; contaminated food [4,186,187]; soil, water and air [5,[188][189][190][191]; colonized animals [39]; birds [192], including migratory species [193]; and even insects (e.g., cockroaches and flies) [194][195][196].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Chelaru,

Muntean,

Hogea

et al. 2024

Antibiotics

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Antimicrobial resistance (AMR) is a worldwide healthcare problem. Multidrug-resistant organisms (MDROs) can spread quickly owing to their resistance mechanisms. Although colonized individuals are crucial for MDRO dissemination, colonizing microbes can lead to symptomatic infections in carriers. Carbapenemase-producing Enterobacterales (CPE) are among the most important MDROs involved in colonizations and infections with severe outcomes. This review aimed to track down the first reports of CPE in Africa, describe their dissemination throughout African countries and summarize the current status of CRE and CPE data, highlighting current knowledge and limitations of reported data. Two database queries were undertaken using Medical Subject Headings (MeSH), employing relevant keywords to identify articles that had as their topics beta-lactamases, carbapenemases and carbapenem resistance pertaining to Africa or African regions and countries. The first information on CPE could be traced back to the mid-2000s, but data for many African countries were established after 2015–2018. Information is presented chronologically for each country. Although no clear conclusions could be drawn for some countries, it was observed that CPE infections and colonizations are present in most African countries and that carbapenem-resistance levels are rising. The most common CPE involved are Klebsiella pneumoniae and Escherichia coli, and the most prevalent carbapenemases are NDM-type and OXA-48-type enzymes. Prophylactic measures, such as screening, are required to combat this phenomenon.

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“…The maximum concentration of air microorganisms in intensive care rooms in each hospital varies based on the standard value of the maximum concentration of microorganisms in the air in each country because each country uses different standard values such as WHO and European Commission standards on indoor air microbial load. This study is based on the regulation of the Minister of Health of the Republic of Indonesia (19).…”

Section: Discussionmentioning

confidence: 99%

Identification of Airborne Aerobic Bacteria in the Intensive Care Room using MALDI-TOF MS

Palulun,

Rasita,

Massi

et al. 2024

JKL

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Introduction: Indoor air quality can affect the spread of airborne microorganisms which can lead to healthcare-associated infections (HAIs). The quality and quantity of airborne microorganisms are responsible for mortality and morbidity in infection-prone hosts such as patients admitted to the intensive care unit (ICU). The research aims to determine the quality of microorganisms in the air, identify the types of aerobic bacteria, and assess the physical parameters of the air in the ICU. Methods: This study was a cross-sectional study with a descriptive observational method. Air specimens were collected using the MAS-100 NT tool with blood agar plate solid culture media, which then incubated in an aerobic atmosphere for 24 hours at 37±2°C. Observation and measurement of air microbiological quality was by counting the number of microorganisms in CFU/m3 and identification of bacteria using MALDI-TOF MS. Results and Discussion: The maximum concentration of microorganisms in the air exceeds the standard value, and the average value of the concentration of microorganisms in the air is 736 CFU/m3. The most common types of aerobic bacteria in the air were Bacillus sp. (n=12), Coagulase-negative Staphylococci (n=5), and Staphylococcus aureus (n=5). There was an increase in physical parameters in the form of average temperature (26.24°C) and humidity (70%) with a ventilation system and air regulation using mechanical ventilation sourced from a split air conditioner with an exhaust fan without a high-efficiency particulate-absorbing (HEPA) filter. Conclusion: Low indoor air quality has the potential to increase the concentration of microorganisms and bacterial findings in the air

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Indoor air microbial load, antibiotic susceptibility profiles of bacteria, and associated factors in different wards of Arba Minch General Hospital, southern Ethiopia

Cited by 12 publications

References 32 publications

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Identification of Airborne Aerobic Bacteria in the Intensive Care Room using MALDI-TOF MS

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