Indoor air pollution concentrations and cardiometabolic health across four diverse settings in Peru: a cross-sectional study

Kephart, Josiah L.; Fandiño-Del-Río, Magdalena; Koehler, Kirsten; Bernabé‐Ortiz, Antonio; Miranda, J. Jaime; Gilman, Robert H.

doi:10.21203/rs.2.21075/v2

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Although some studies have found positive associations between HAP and CRP, 54,56 others have also found null associations 57,74,75 . Two previous studies in Puno did not identify CRP associations with biomass stove users 53,76 . However, lifestyle differences (ie, more physical activity among rural participants who primarily worked as farmers) may have contributed to the lower concentrations of CRP observed among rural participants 53 .…”

Section: Discussionmentioning

confidence: 96%

Household air pollution and blood markers of inflammation: A cross‐sectional analysis

et al. 2021

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Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross‐sectional exposure‐response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL‐6, IL‐10, IL‐1β, and TNF‐α) with dried blood spots, 48‐h kitchen area concentrations and personal exposures to fine particulate matter (PM2.5), black carbon (BC), and carbon monoxide (CO), and 48‐h kitchen concentrations of nitrogen dioxide (NO2) in a subset of 97 participants. We conducted an exposure‐response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM2.5. As expected, kitchen area BC concentrations were positively associated with TNF‐α (pro‐inflammatory) concentrations and negatively associated with IL‐10, an anti‐inflammatory marker, controlling for confounders in single‐ and multi‐pollutant models. However, contrary to expectations, kitchen area BC and NO2 concentrations were negatively associated with IL‐1β, a pro‐inflammatory marker. No associations were identified for IL‐6 or CRP, or for any marker in relation to personal exposures.

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Section: Discussionmentioning

confidence: 96%

Household air pollution and blood markers of inflammation: A cross‐sectional analysis

et al. 2021

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“…It is also possible that the observed BP elevation in the intervention group, observed in the ITT analysis, was attributable to exposures to other unmeasured pollutants from using the LPG stove, such as nitrogen dioxide, 43 polycyclic aromatic hydrocarbons, 44 and volatile organic compounds. 45 More comprehensive personal HAP exposure characterization is needed to fully understand the effect of specific HAP constituents on BP.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial

Steenland

Quinn

et al. 2022

Hypertension

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Background: Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies. Methods: We recruited 3195 pregnant women in Guatemala, India, Peru, and Rwanda and randomly assigned them to intervention or control groups. The intervention group received a gas stove and fuel during pregnancy, while the controls continued cooking with solid fuels. We measured BP and personal exposure to PM 2.5 , black carbon and carbon monoxide 3× during gestation. We conducted an intention-to-treat and exposure-response analysis to determine if household air pollution exposure was associated with increased gestational BP. Results: Median 24-hour PM 2.5 dropped from 84 to 24 μg/m 3 after the intervention; black carbon and carbon monoxide decreased similarly. Intention-to-treat analyses showed an increase in systolic BP and diastolic BP in both arms during gestation, as expected, but the increase was greater in intervention group for both systolic BP (0.69 mm Hg [0.03–1.35]; P =0.04) and diastolic BP (0.62 mm Hg [0.05–1.19]; P =0.03). The exposure-response analyses suggested that higher exposures to household air pollution were associated with moderately higher systolic BP and diastolic BP; however, none of these associations reached conventional statistical significance. Conclusions: In intention-to-treat, we found higher gestational BP in the intervention group compared with controls, contrary to expected. In exposure-response analyses, we found a slight increase in BP with higher exposure, but it was not statistically significant. Overall, an intervention with gas stoves did not markedly affect gestational BP.

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Indoor air pollution concentrations and cardiometabolic health across four diverse settings in Peru: a cross-sectional study

Cited by 2 publications

References 29 publications

Household air pollution and blood markers of inflammation: A cross‐sectional analysis

Household air pollution and blood markers of inflammation: A cross‐sectional analysis

Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial

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