The indoor air of a hospital is always full of bacteria and viruses due to patients with different diseases. These bacteria and viruses could be highly infectious to the people in the hospital irrespective of their health conditions, and could be hazardous to the patients, their care takers, and hospital staff. Thus, keeping a good hospital air quality is very essential to the operation of the hospital. This study aims at enhancing ventilation of the interior lighting of hospitals with germicidal capabilities. Air disinfection is accomplished by adding the specially designed disinfecting filters and fans to existing embedded lamps in the hospitals. The embedded lamp has a square shape of 601 mm in width and 112 mm in thickness. In the design stage, the air flow inside the embedded lamp with the added filters and fans was investigated by numerical simulation using a computational fluid dynamics (CFD) tool. Three designs, referred to as Types 1, 2, and 3, were evaluated using steady-state CFD flow simulations. The ventilation rate of the Type 1 design was about 251.9 CMH, and 348.3 CMH for the Type 2 design by increasing the fan outlet area. However, even though the ventilation was increased by 34%, the flow field of the Type 2 design was not uniform, resulting in flows being circulated around the side locations. Thus, the Type 3 design further treats this aspect by streamlining the outlet geometry and adding flow guiding vanes to reduce flow resistance and flow unsteadiness; the corresponding air ventilation rate reached 376.3 CMH. Hence, the Type 3 design was fabricated and tested. The test results confirm that the design not only has a higher ventilation rate but also operates under a smaller pressure drop, thus accomplishing the goal of providing good air quality in the hospital environment efficiently. Moreover, the associated flow noise is reduced by about 8 dBA. Hence, both an increase in the air ventilation rate and a reduction of noise are achieved simultaneously by the present method.