Indoor environmental factors associated with wheezing illness and asthma in South Korean children: phase III of the International Study of Asthma and Allergies in Childhood

Chae, Yoomi; Hahm, Myung-Il; Ahn, Kangmo; Kim, Jihyun; Kim, Woo Kyung; Lee, So‐Yeon; Park, Yong Mean; Han, Man Yong; Lee, Kee Jae; Kwon, Ho-Jang

doi:10.3109/02770903.2014.930879

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Interestingly, boys are more likely to have certain atopic diseases in childhood, including rhinitis and asthma. 38,39 This gender difference provides some evidence of an association between ATH and allergies. A cohort study showed that boys exhibited higher interferon-gamma, interleukin (IL)-5, and IL-13 responses, indicating different cytokine responses and suggesting that these elevated responses might lead to sex-specific atopic characteristics during childhood.…”

Section: Discussionmentioning

confidence: 93%

Local Atopy in Childhood Adenotonsillar Hypertrophy

Cho

Kim

Hong

et al. 2018

Am J Rhinol�Allergy

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Background Although the cause of adenotonsillar hypertrophy remains unknown, some studies have shown that allergy may be a risk factor. Purpose This study determined the levels of allergen-specific immunoglobulin E (sIgE) in the adenotonsillar tissues of children with adenotonsillar hypertrophy and evaluated the clinical significance of local atopy in adenotonsillar tissues. Methods We measured 21 types of specific immunoglobulin E in the serum and adenotonsillar tissues of 102 children with adenotonsillar hypertrophy and compared the sensitization patterns of the serum and local tissues. The patients were divided into three groups-atopy, local atopy, and nonatopy-according to the sensitization of serum and adenotonsillar tissues, and the clinical symptoms among the groups were analyzed. Results Seventy-two (70.6%) children with adenotonsillar hypertrophy were sensitized to more than one allergen in the serum and/or adenotonsillar tissue. Thirty (29.4%) children had no IgE positivity to any allergen in both serum and adenotonsillar tissues. Fifty-five (53.9%) were sensitized to at least one allergen in the serum. Seventy (68.6%) were sensitized to at least one allergen in the adenotonsillar tissue. Seventeen (36.2%) of 47 children with specific immunoglobulin E-negative serum had specific immunoglobulin E-positive adenotonsillar tissues. The rate of specific immunoglobulin E was significantly higher in local tissues than in serum. The rate of inhalant allergen specific immunoglobulin E was significantly higher in the adenoids than in the tonsils. However, the rate of food allergen specific immunoglobulin E was significantly higher in the tonsils than adenoids. The lifetime prevalence of asthma and allergic rhinitis, recent symptoms or treatment of allergic rhinitis, and severity of nasal symptoms (rhinorrhea, sneezing, and nasal itching) were significantly higher in children with local atopy than with nonatopy. Conclusions These results confirm that allergic response may be a risk factor for adenotonsillar hypertrophy. Local allergic inflammation may play an important role in childhood adenotonsillar hypertrophy, and local atopy in adenotonsillar tissues can cause respiratory allergic symptoms in children.

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Section: Discussionmentioning

confidence: 93%

Local Atopy in Childhood Adenotonsillar Hypertrophy

Cho

Kim

Hong

et al. 2018

Am J Rhinol�Allergy

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“…Overall, 91 studies in Asia investigated the associations between the family history of various allergy-related diseases and the risk of asthma development [ 20 , 22 , 23 , 25 – 27 , 31 , 32 , 34 – 36 , 42 , 44 – 46 , 51 , 52 , 57 , 59 , 62 , 65 – 68 , 70 – 73 , 76 – 79 , 82 – 140 ]. Among these, the family medical history of asthma (any family members) was most frequently studied and significantly associated with an increased risk of asthma (36 studies) [ 20 , 25 – 27 , 32 , 34 , 35 , 44 – 46 , 51 , 57 , 59 , 76 , 77 , 79 , 82 , 83 , 86 , 95 , 101 , 102 , 104 – 106 , 108 – 110 , 112 , 116 , 123 , 128 , 129 , 133 , 137 , 140 , 141 ].…”

Section: Resultsmentioning

confidence: 99%

“…The association between gender and asthma was reported in 75 studies [ 16 , 18 , 19 , 21 , 22 , 33 , 35 , 37 , 38 , 40 , 42 , 43 , 47 , 49 , 56 , 58 , 62 , 67 , 70 , 71 , 73 , 74 , 79 , 82 – 87 , 92 , 93 , 95 , 97 , 99 , 104 , 105 , 107 , 110 , 116 , 118 , 120 , 122 , 124 – 127 , 130 , 131 , 133 , 135 – 137 , 139 , 142 , 159 , 170 , 179 , 184 – 201 ]. Of these, 58 studies have observed male subjects having a higher asthma susceptibility as compared with that of the female subjects significantly [ 16 , 18 , 22 , 37 , 38 , 40 , 47 , 56 , 58 , 62 , 67 , 70 , 71 , 73 , 74 , …”

Section: Resultsmentioning

confidence: 99%

Risk factors of asthma in the Asian population: a systematic review and meta-analysis

Sio

Chew

2021

J Physiol Anthropol

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Background and objective An increasing trend of asthma prevalence was observed in Asia; however, contributions of environmental and host-related risk factors to the development of this disease remain uncertain. This study aimed to perform a systematic review and meta-analysis for asthma-associated risk factors reported in Asia. Methods We systematically searched three public databases (Web of Science, PubMed, and Scopus) in Feb 2021. We only included articles that reported environmental and host-related risk factors associated with asthma in the Asian population. Random-effect meta-analyses were conducted for frequently reported asthma-associated risk factors to provide an overall risk estimate of asthma development. Results Of 4030 records obtained from public databases, 289 articles were selected for review. The most frequently reported asthma-associated risk factor was the family history of allergy-related conditions. The random-effect asthma risk estimates (pooled odds ratio, OR) were 4.66 (95% confidence interval (CI): 3.73–5.82) for the family history of asthma, 3.50 (95% CI: 2.62–4.67) for the family history of atopy, 3.57 (95% CI: 3.03–4.22) for the family history of any allergic diseases, 1.96 (95% CI: 1.47–2.61) for the family history of allergic rhinitis, and 2.75 (95% CI: 1.12–6.76) for the family history of atopic dermatitis. For housing-related factors, including the presence of mold, mold spots, mold odor, cockroach, water damage, and incense burning, the random-effect pooled OR ranged from 1.43 to 1.73. Other risk factors with significant pooled OR for asthma development included male gender (1.30, 95% CI: 1.23–1.38), cigarette smoke exposure (1.44, 95% CI: 1.30–1.60), cigarette smoking (1.66, 95% CI: 1.44–1.90), body mass index (BMI)–related parameters (pooled OR ranged from 1.06 to 2.02), various types of air pollution (NO2, PM10, and O3; pooled OR ranged from 1.03 to 1.22), and pre- and perinatal factors (low birth weight, preterm birth, and cesarean section; pooled OR ranged from 1.14 to 1.32). Conclusions The family history of asthma was the most frequently reported risk factor for asthma development in Asia with the highest risk estimate for asthma development. This suggests a major role of the genetic component in asthma pathogenesis. Further study on asthma genetics is required to improve the current understanding of asthma etiology.

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“…We also found that boys had significantly higher total IgE levels than girls. Boys are more likely to have a number of atopic diseases such as rhinitis and asthma in childhood (2324). A birth cohort study showed distinctive patterns of cytokine responses between girls and boys (13).…”

Section: Discussionmentioning

confidence: 99%

Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren

et al. 2017

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The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic diseases. A nationwide, cross-sectional survey was conducted in first grade students from randomly selected elementary and middle schools. Total IgE levels were measured by ImmunoCAP. Skin prick tests were performed for 18 common inhalant allergens to determine the presence of atopy. Children aged 12–13 years and parents of children aged 6–7 years were asked to complete questionnaire assessing allergic diseases. The cut-off levels of total IgE were determined by analyzing receiver operating characteristic curves. The median total IgE level was 86.7 kU/L (range: 1.5–4,523.1) in 3,753 children aged 6–7 years and 94.7 kU/L (range: 1.5–3,000.0) in 3,930 children aged 12–13 years. Total IgE concentrations were higher in children with atopy or allergic diseases than in those without (all P < 0.001). At the cut-off value of 127.7 kU/L, sensitivity, specificity, and positive and negative predictive values (PPV and NPV) were 67.1%, 75.4%, 65.4%, and 76.7%, respectively, in elementary schoolchildren. At the cut-off value of 63.0 kU/L, sensitivity, specificity, PPV, and NPV were 81.9%, 66.6%, 75.0%, and 75.1%, respectively, in middle schoolchildren. PPV and NPV were ≥ 70% when cut-offs of 258.8 kU/L and 38.4 kU/L were used for the diagnosis of atopy in 6–7 year-olds and 12–13 year-olds, respectively. This nationwide population-based study provided the first normal reference ranges of total IgE in Korean schoolchildren.

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Indoor environmental factors associated with wheezing illness and asthma in South Korean children: phase III of the International Study of Asthma and Allergies in Childhood

Abstract: Although the risk factors for current asthma appear to be more related to the non-modifiable risk factors like sex, parental history of allergic diseases, SPT, the two groups are associated with exposure to modifiable indoor environmental factors.

Cited by 4 publications

References 22 publications

Local Atopy in Childhood Adenotonsillar Hypertrophy

Local Atopy in Childhood Adenotonsillar Hypertrophy

Risk factors of asthma in the Asian population: a systematic review and meta-analysis

Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren

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