Indoor fungal diversity and asthma: A meta-analysis and systematic review of risk factors

Sharpe, Richard; Bearman, Nick; Thornton, Christopher R.; Husk, Kerryn; Osborne, Nicholas J.

doi:10.1016/j.jaci.2014.07.002

Cited by 251 publications

(195 citation statements)

References 69 publications

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“…(1-3)-B-D-Glucan is a principle cell wall structure of fungi and other microorganisms, comprising about 60% of fungal cell wall (Sharpe et al, 2015).…”

Section: Airborne Fungal Spores and Allergymentioning

confidence: 99%

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Fayad

2016

Qatar University Life Science Symposium 2016: Biodiversity, Sustainability and Climate Change, With Perspectives From Qatar

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“…(1-3)-B-D-Glucan is a principle cell wall structure of fungi and other microorganisms, comprising about 60% of fungal cell wall (Sharpe et al, 2015).…”

Section: Airborne Fungal Spores and Allergymentioning

confidence: 99%

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Fayad

2016

Qatar University Life Science Symposium 2016: Biodiversity, Sustainability and Climate Change, With Perspectives From Qatar

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“…Associated to the decrease in temperature due to reduced heating (notably for economic reasons), this results in higher humidity in dwellings, thus promoting development of molds (Reboux et al, 2009). This is of major concern in large parts of industrialized countries (USA, Canada and Europe), since (i) between 4 and 40% of dwellings in these countries appear to be affected by dampness, (ii) people spend between 80 and 90% of their time indoor and (iii) many studies already demonstrated adverse effects of dampness and mold exposure on respiratory health particularly in children (Bornehag et al, 2001;Deguen et al, 2012;Fisk et al, 2010;Heinrich, 2011;Kanchongkittiphon et al, 2015;Sharpe et al, 2015;World Health Organization, 2009). …”

Section: Introductionmentioning

confidence: 99%

Concentration and determinants of molds and allergens in indoor air and house dust of French dwellings

Dallongeville

Cann

Zmirou‐Navier

et al. 2015

Science of The Total Environment

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Molds and allergens are common indoor biocontaminants. The aims of this study were to assess the concentrations of common molds in indoor air and floor dust and the concentrations of house dust mite, cat and dog allergens in mattress dust in French dwellings, and to assess predictors of these concentrations. A sample of 150 houses in Brittany (western France) was investigated.Airborne Cladosporium and Penicillium were detected in more than 90% of the dwellings, Aspergillus in 46% and Alternaria in only 6% of the housings. Regarding floor dust samples, Cladosporium and Penicillium were detected in 92 and 80% of the housings respectively, Aspergillus in 49% and Alternaria in 14%. House dust mite allergens Der p1 and Der f1 were detected in 90% and 77% of the mattress dust samples respectively and Can f1 and Fel d1 in 37% and 89% of the homes. Airborne and dustborne mold concentrations, although not statistically correlated (except for Aspergillus) shared most of their predictors. Multivariate linear models for mold levels, explaining up to 62% of the variability, showed an influence of the season, of the age of the dwelling, of aeration habits, presence of pets, smoking, signals of dampness, temperature and relative humidity. Allergens in the dust of the mattress were strongly related to the presence of pets and cleaning practices of bedsheets, these factors accounting for 60% of the variability. This study highlights ubiquitous contamination by molds and underlines complex interaction between outdoor and indoor sources and factors.3

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“…Using a meta-analysis, Sharpe et al [133] summarized that an increase in asthma exacerbation in children around the world correlated with exposure levels of Alternaria, Aspergillus, Cladosporium, and Penicillium species.…”

Section: Mold Allergens and Asthmamentioning

confidence: 99%

Protein Biomarkers in Asthma

Karaulov

Garib

et al. 2018

Int Arch Allergy Immunol

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Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.

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Indoor fungal diversity and asthma: A meta-analysis and systematic review of risk factors

Cited by 251 publications

References 69 publications

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Concentration and determinants of molds and allergens in indoor air and house dust of French dwellings

Protein Biomarkers in Asthma

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