In the era of mobile Internet, the application of various positioning-based location service systems is becoming more and more common. In addition, the traditional radio positioning system is limited in the use of special environments such as mines, hospitals, and gas stations, and long-term electromagnetic radiation can cause potential damage to the human body. Compared with the traditional wireless positioning technology, VLC-based positioning technology has a good application prospect in the field of indoor wireless positioning. Compared with traditional radio positioning technology, the use of VLC technology to achieve indoor positioning is different in that the system design and layout need to consider the basic needs of indoor lighting; that is, the layout of multiple visible light sources in the room should meet the minimum illumination requirements of any area of the room. Since the layout structure of the light source that only considers the lighting requirements or only considers the positioning accuracy requirements is not the same, in the design process of the indoor visible light wireless positioning system, it is necessary to consider the overall optimization layout of multiple indoor visible light sources under the conditions of lighting and positioning constraints. This paper mainly optimizes indoor positioning from the aspects of light source layout, reflected light intensity distribution, and noise model.