Background: The sick building syndrome (SBS) describes situations in which building occupants experience acute negative physical and mental effects linked to the time spent in a contaminated area without any identified illness. Objective: The study was carried out in order to assess the prevalence of SBS among primary school students in Qom, Iran, and the association between SBS symptoms and personal, psychosocial and environmental factors.. Method: A descriptive-analytical study was conducted on 24 primary schools in different regions of Qom, Iran, from 15 September 2014 to 27 February 2015. Four hundred and twenty students, comprising an equal number of randomly selected males and females, aged 7-13 years, participated in the study. A standardized questionnaire was completed by 397 (94.5 %) students. Data was then analysed using SPSS software. Results: Twenty four percent of students, comprising 65.3% of female and 34.7% of male students, had SBS. The most frequent symptom of SBS was headache identified in 39 (10%) cases. A significant difference was observed between SBS symptoms and gender (p = 0.001). Whilst SBS had a significant direct correlation with the age of the school building (p= 0.001) there was a significant _________________________________________