Indoor tanning exposure in association with multiple primary melanoma

Karapetyan, Lilit; Yang, Xi; Wang, Hong; Sander, Cindy; Moyer, Ashley; Wilson, Melissa; Karunamurthy, Arivarasan; Kirkwood, John M.

doi:10.1002/cncr.33307

Cited by 8 publications

(13 citation statements)

References 27 publications

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“…We performed age‐, sex‐, and stage‐matched studies within the biospecimen repository of this institution. These factors are important to account for because we previously reported that patients with MPMs were younger at time of diagnosis of first primary melanoma, and more likely to be diagnosed at stage 0 or 1 3 . Our MPM cohort also shows female predominance, whereas melanoma has been classically viewed as a male‐biased disease 15 .…”

Section: Discussionmentioning

confidence: 80%

“…These factors are important to account for because we previously reported that patients MPMs were younger at time of diagnosis of first primary melanoma, and more likely to be diagnosed at stage 0 or 1. 3 Our MPM cohort also shows female predominance, whereas melanoma has been classically viewed as a male-biased disease. 15 The major limitations included the number of samples reporting TILs and with PBMCs available for transcriptional profiling, although these results were exploratory in nature.…”

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confidence: 76%

“…Patients with melanoma are at increased risk (1%‐8%) of subsequent melanoma based on multiple reports, with the highest risk occurring within 2 years of first primary melanoma diagnosis 1,2 . Subsequent melanomas tend to be thinner, are diagnosed at stage I or stage 0 (in situ) and are more likely to present in different anatomical locations 3 . The impact of subsequent melanomas on patient prognosis remains poorly resolved.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Subsequent melanomas tend to be thinner, are diagnosed at stage I or stage 0 (in situ) and are more likely to present in different anatomical locations. 3 The impact of subsequent melanomas on patient prognosis remains poorly resolved.…”

Section: Introductionmentioning

confidence: 99%

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Poorer survival outcomes in patients with multiple versus single primary melanoma

Karapetyan

Yang

Knight

et al. 2022

Cancer

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BACKGROUND:Given equivocal results related to overall survival (OS) for patients with multiple primary melanomas (MPMs) compared with those with single primary melanomas (SPMs) in previous reports, the authors sought to determine whether OS differs between these 2 cohorts in their center using their UPCI-96-99 database. Secondary aims were to assess the differences in recurrence-free survival (RFS). In a subset of patients, transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) was performed to assess disease-associated genes of interest. METHODS: This retrospective case-controlled study included patients with MPMs and age-, sex-, and stage-matched controls with SPMs at a 1:1 ratio. Cox regression models were used to evaluate the effect of the presence of MPMs on death and recurrence. NanoString PanCancer Immune Profiling was used to assess peripheral blood immune status in patients. RESULTS: In total, 320 patients were evaluated. The mean patient age was 47 years; 43.8% were male. Patients with MPMs had worse RFS and OS (P = .023 and P = .0019, respectively). The presence of MPMs was associated with an increased risk of death (hazard ratio [HR], 4.52, P = .0006), and increased risk of disease recurrence (HR, 2.17; P = .004) after adjusting for age, sex, and stage. The degree of tumor-infiltrating lymphocytes (TILs) was different between the first melanoma of MPMs and SPMs. Expression of CXCL6 and FOXJ1 was increased in PBMCs isolated from patients with MPMs. CONCLUSIONS: Patients with MPMs had worse RFS and OS compared with patients with SPMs. Immunologic differences were also observed, including TIL content and expression of CXCL6/FOXJ1 in PBMCs of patients with MPMs, which warrant further investigation.

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Poorer survival outcomes in patients with multiple versus single primary melanoma

Karapetyan

Yang

Knight

et al. 2022

Cancer

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“…Tanning bed usage and the initiation of tanning behavior at a younger age have both been implicated in incidences of melanoma at a significantly younger age [ 42 , 43 ]. Beyond the risk of developing an initial melanoma, indoor tanning practices are significantly associated with the development of multiple primary melanomas [ 44 ]. Given the increased risk of melanoma in the context of tanning behavior, tanning is not a recommended practice for either vitamin D supplementation or for cosmetic reasons.…”

Section: Sun-seeking Behaviors and Melanoma Developmentmentioning

confidence: 99%

Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence

Djavid

Stonesifer

Fullerton

et al. 2021

Cancers

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(1) Melanoma is the most aggressive dermatologic malignancy, with an estimated 106,110 new cases to be diagnosed in 2021. The annual incidence rates continue to climb, which underscores the critical importance of improving the methods to prevent this disease. The interventions to assist with melanoma prevention vary and typically include measures such as UV avoidance and the use of protective clothing, sunscreen, and other chemopreventive agents. However, the evidence is mixed surrounding the use of these and other interventions. This review discusses the heritable etiologies underlying melanoma development before delving into the data surrounding the preventive methods highlighted above. (2) A comprehensive literature review was performed to identify the clinical trials, observational studies, and meta-analyses pertinent to melanoma prevention and incidence. Online resources were queried to identify epidemiologic and clinical trial information. (3) Evidence exists to support population-wide screening programs, the proper use of sunscreen, and community-targeted measures in the prevention of melanoma. Clinical evidence for the majority of the proposed preventive chemotherapeutics is presently minimal but continues to evolve. (4) Further study of these chemotherapeutics, as well as improvement of techniques in artificial intelligence and imaging techniques for melanoma screening, is warranted for continued improvement of melanoma prevention.

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Multiple primary melanoma in association with other personal and familial cancers

et al. 2022

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Background Multiple primary melanoma (MPM) is known to be associated with familial melanoma. However, the association between MPM and other personal and familial cancers is not well documented. The objective of this study was to evaluate the association between MPM and personal history of other cancers or cancer history among first‐degree relatives (FDRs). Methods We performed a retrospective case–control study including cases with gender‐matched MPM and single primary melanoma (SPM) at a 1:2 ratio from the University of Pittsburgh Cancer Institute Melanoma Center Biological Sample and Nevus Bank. The associations between MPM and other cancers were evaluated using univariable and multivariable logistic regression models. Results In total, 378 patients (44.2% men; median age 52 years) were enrolled, including 252 with SPM and 126 with MPM. In comparison to patients with SPM, patients with MPM were more likely to have squamous cell carcinoma (odds ratio [OR] 1.95, 95% confidence interval [CI] 1.001–3.79, p = 0.047) and prostate cancer (OR 2.72, 95% CI 1.07–7.01, p = 0.034). FDRs of patients with MPM had higher prevalence of melanoma (OR 2.37, 95% CI 1.31–4.28, p = 0.004) and prostate cancer (OR 2.92, 95% CI 1.47–6.14, p = 0.002) but not other cancers. In multivariable analysis, the association remained significant between MPM and squamous cell carcinoma (OR 2.18, 95% CI 1.08–4.39, p = 0.028), prostate cancer (OR 2.85, 95% CI 1.09–7.54, p = 0.032), FDR history of melanoma (OR 2.37, 95% CI 1.31–4.29, p = 0.004), and FDR history of prostate cancer (OR 3.26, 95% CI 1.59–6.83, p = 0.001). Conclusions Patients with MPM have a higher prevalence of personal and FDR histories of nonmelanoma skin cancers and prostate cancer.

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Indoor tanning exposure in association with multiple primary melanoma

Cited by 8 publications

References 27 publications

Poorer survival outcomes in patients with multiple versus single primary melanoma

Poorer survival outcomes in patients with multiple versus single primary melanoma

Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence

Multiple primary melanoma in association with other personal and familial cancers

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