Induced ischemia detected by dobutamine stress echocardiography in coronary heart disease patients after myocardial re-vascularization.

Lorenzo, F. De; Saba, Neelam; Dancy, Mark; Kakkar, Vijay V.; Kadziola, Zbigniew; Xiao, Han

doi:10.1016/s0167-5273(02)00029-3

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…These results were observed in the presence of a remarkable impact of risk factor control measures in both treatment groups. Previous studies in patients with silent ischaemia showed the prognostic importance of this finding in patients with additional angina, 9,14 previous MI, 10,11 coronary artery bypass graft surgery, 12 or angioplasty. 13 The prognostic importance of silent ischaemia type I documented by stress MPS was also described in asymptomatic volunteers and elderly subjects.…”

Section: Discussionmentioning

confidence: 78%

“…[6][7][8] The prognostic impact of silent ischaemia has been studied in type II and III patients, i.e. in patients with angina pectoris 9 or following myocardial infarction (MI) 10,11 as well as in patients after coronary artery bypass graft surgery 12 or angioplasty. 13 In addition, the prospective Asymptomatic Cardiac Ischemia Pilot study and the Atenolol Silent Ischemia Study have shown benefit of revascularization 14 or drug therapy 14,15 in patients who had silent ischaemic episodes in addition to symptomatic ones.…”

Section: Introductionmentioning

confidence: 99%

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Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study

Erné

Schoenenberger

Züber

et al. 2007

European Heart Journal

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Aims To determine the effect of anti-ischaemic drug therapy on long-term outcomes of asymptomatic patients without coronary artery disease (CAD) history but silent exercise ST-depression. Methods and results In a randomized multicentre trial, 263 of 522 asymptomatic subjects without CAD but at least one CAD risk factor in whom silent ischaemia by exercise ECG was confirmed by stress imaging were asked to participate. The 54 (21%) consenting patients were randomized to anti-anginal drug therapy in addition to risk factor control (MED, n ¼ 26) or risk factor control-only (RFC, n ¼ 28). They were followed yearly for 11.2 + 2.2 years. During 483 patient-years, cardiac death, non-fatal myocardial infarction, or acute coronary syndrome requiring hospitalization or revascularization occurred in 3 (12%) of MED vs. 17 (61%) of RFC patients (P , 0.001). In addition, MED patients had consistently lower rates of exerciseinduced ischaemia during follow-up, and left ventricular ejection fraction remained unchanged (20.7%, P ¼ 0.597) in contrast to RFC patients in whom it decreased over time (26.0%, P ¼ 0.006). Conclusion Anti-ischaemic drug therapy and aspirin seem to reduce cardiac events in subjects with asymptomatic ischaemia type I. In such patients, exercise-induced ST-segment depression should be verified by stress imaging; if silent ischaemia is documented, anti-ischaemic drug therapy and aspirin should be considered.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study

Erné

Schoenenberger

Züber

et al. 2007

European Heart Journal

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“…ILENT ISCHEMIA HAS BEEN SHOWN to predict adverse prognosis in patients after myocardial infarction (MI), 1 coronary artery bypass graft surgery, 2 and percutaneous coronary intervention (PCI) with or without stenting. [3][4][5][6] Despite these consistent findings, there are few prospective data unequivocally documenting a benefit of anti-ischemic therapy on prognosis in patients with silent ischemia.…”

mentioning

confidence: 99%

Effects of Percutaneous Coronary Interventions in Silent Ischemia After Myocardial Infarction

Erné¹,

Schoenenberger²,

Burckhardt³

et al. 2007

JAMA

289

122

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“…Отсутствие недоро гих высокоинформативных неинвазивных методов диагностики ИБС приводит к увеличению необос нованно проведенных КАГ. Диагностическая цен ность стандартных методов стресс ЭхоКГ неодно значна, учитывая ее высокую специфичность и недостаточную чувствительность при одних стресс -агентах [дипиридамол, чреспищеводная стимуля ция предсердий (ЧПЭСП)] и противоположное со отношение этих показателей в других пробах (физи ческая нагрузка, добутамин) [16,17,18,19,20,21].…”

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Noninvasive Diagnostic Technique in Stenotic Coronary Atherosclerosis

Васильев¹,

Михеев²,

Макарова³

2005

rmt

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Induced ischemia detected by dobutamine stress echocardiography in coronary heart disease patients after myocardial re-vascularization.

Cited by 7 publications

References 17 publications

Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study

Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study

Effects of Percutaneous Coronary Interventions in Silent Ischemia After Myocardial Infarction

Noninvasive Diagnostic Technique in Stenotic Coronary Atherosclerosis

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