Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway

Ma, Yizhao; Xu, Xiaonan; Li, Chunhong; Wang, Yi; Zhu, Jie; Xia, Xiaohuan; Zheng, Jialin

doi:10.1111/cns.13744

Cited by 11 publications

(16 citation statements)

References 19 publications

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“…Some of these non-coding RNAs have been shown to accumulate within MSC-EVs [ 54 ]. Interestingly, as reported by previous [ 32 ] and recent [ 54 , 55 , 56 ] studies, the preliminary and advanced stages of AD can be easily distinguished. The age of AD patients is critically important for their therapy, as specifically discussed in Section 4 .…”

Section: Role Of the Extracellular Vesicles From Mesenchymal Stem Cells: Recent Views About The Alzheimer’s Diseasesupporting

confidence: 59%

“…In fact, the efforts to reduce Aβ synthesis by blockers of BACE-1, and those with anti-tau and anti-Aβ antibodies, were found unable to reduce the structural devastations induced by the disease in critical areas of the brain. A posteriori, it is not surprising that the drugs, inactive on fully developed disease patients, are effective in healthy persons destined to develop the disease in the future, and in patients at an early stage of the disease, reducing and slowing down their later development of AD [ 33 , 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Traumas and ischemic lesions can be induced in both the brain and spinal cord. In many cases, the recovery induced by low doses of MSC-EVs has been shown to start with activation of few receptors, followed by phosphorylation of kinases and various factors, and by activation of miRNAs [ 56 , 57 , 58 , 59 ]. Analogously, MSC-EVs have been shown to mitigate trained immune responses induced by innate cells, with distinct local repair [ 60 ].…”

Section: Role Of the Extracellular Vesicles From Mesenchymal Stem Cells: Recent Views About The Alzheimer’s Diseasementioning

confidence: 99%

“…However, intense studies of many AD patients came out largely unsuccessful, as documented by clinical trial attempts that were either concluded without benefit or discontinued [ 4 , 5 ]. Clear positive effects were observed only in healthy persons destined to develop the disease in the future, and in very early patients [ 3 , 63 ], identified by appropriate markers [ 33 , 54 , 55 , 56 ]. Based on the long-term experience in the field, the investigation of BACE-1 and immune therapies has been pursued up to now.…”

Section: Present Therapies For Alzheimer’s Diseasementioning

confidence: 99%

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News about Therapies of Alzheimer’s Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments

Meldolesi

2022

Biomedicines

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Upon its discovery, Alzheimer’s, the neurodegenerative disease that affects many millions of patients in the world, remained without an effective therapy. The first drugs, made available near the end of last century, induced some effects, which remained only marginal. More promising effects are now present, induced by two approaches. Blockers of the enzyme BACE-1 induce, in neurons and glial cells, decreased levels of Aβ, the key peptide of the Alzheimer’s disease. If administered at early AD steps, the BACE-1 blockers preclude further development of the disease. However, they have no effect on established, irreversible lesions. The extracellular vesicles secreted by mesenchymal stem cells induce therapy effects analogous, but more convenient, than the effects of their original cells. After their specific fusion to target cells, the action of these vesicles depends on their ensuing release of cargo molecules, such as proteins and many miRNAs, active primarily on the cell cytoplasm. Operationally, these vesicles exhibit numerous advantages: they exclude, by their accurate selection, the heterogeneity of the original cells; exhibit molecular specificity due to their engineering and drug accumulation; and induce effective actions, mediated by variable concentrations of factors and molecules and by activation of signaling cascades. Their strength is reinforced by their combination with various factors and processes. The recent molecular and operations changes, induced especially by the stem cell target cells, result in encouraging and important improvement of the disease. Their further development is expected in the near future.

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Section: Role Of the Extracellular Vesicles From Mesenchymal Stem Cells: Recent Views About The Alzheimer’s Diseasesupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Role Of the Extracellular Vesicles From Mesenchymal Stem Cells: Recent Views About The Alzheimer’s Diseasementioning

confidence: 99%

Section: Present Therapies For Alzheimer’s Diseasementioning

confidence: 99%

See 2 more Smart Citations

News about Therapies of Alzheimer’s Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments

Meldolesi

2022

Biomedicines

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“…5 Our previous studies found that iNPC-EVs are with proliferation and cell survival promotion potential no less than NPC-EVs in vitro, indicating iNPC-EVs as eligible substitutes of NPC-EVs. 6,7 Herein, we compared the therapeutic effects of NPC-EVs and iNPC-EVs on a model of IS using transient middle cerebral artery occlusion (MCAO) mice. MCAO was validated by triphenyltetrazolium chloride staining (Figure S1).…”

mentioning

confidence: 99%

Induced neural stem/progenitor cell‐derived extracellular vesicles promote recovery post‐stroke

Gao

Zhu

et al. 2022

Clinical & Translational Med

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Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Tan,

Xu,

et al. 2024

Advanced Therapeutics

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Stem cell‐derived small extracellular vesicles that are either naturally produced or pharmacogenetically engineered have shown tremendous potential in regenerative medicine in recent years. These sEVs exert multiple therapeutic effects comparable or superior to their parental stem cells while avoiding the limitations of stem cell‐based therapy, such as infusion toxicity, immunogenicity, tumorigenic potential, and ethical issues. The two routine modalities of sEV administration are systemic injection and local delivery, each presenting distinct benefits and drawbacks. Various biomaterials have been developed to assist their local delivery to improve the targeting of organs, minimize non‐specific accumulation in vital organs, and ensure the protection and release of sEVs. Based on a thorough search and meticulous dissection of relevant literature from the past five years, we present this comprehensive, up‐to‐date, specialty‐specific, disease‐oriented, and preclinical review to expound on the surgical application and potential of stem cell‐derived sEVs. The local delivery of stem cell‐derived sEVs, which possess similar indications as systemic transfer, could treat numerous diseases encountered in orthopedic surgery, neurosurgery, plastic surgery, cardiothoracic surgery, general surgery, urology, otorhinolaryngology, ophthalmology, obstetrics and gynecology, and dental surgery. In addition, the biomaterials utilized encompass a wide range of sources (e.g., natural, synthetic, and hybrid polymers), format (e.g., scaffold, patch, spray, microneedle), and responsiveness (e.g., temperature, pH, and protein), which enables customized sEV therapy tailored to specific diseases. This review demonstrates biomaterial‐facilitated local delivery of stem cell‐derived sEVs as a viable alternative or even a superior option to systemic sEV therapy. Future collaboration among surgeons, biomaterial scientists, and stem cell researchers is essential to advance this research area.This article is protected by copyright. All rights reserved

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Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway

Cited by 11 publications

References 19 publications

News about Therapies of Alzheimer’s Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments

News about Therapies of Alzheimer’s Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments

Induced neural stem/progenitor cell‐derived extracellular vesicles promote recovery post‐stroke

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

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