Induced osteogenesis by periosteal distraction

The mechanobiological effects of periosteal surface loads

“…Together, these two sets of experiments would help to determine the specific biological mechanisms that produce bone modeling effects with impeded blood flow and direct cellular deformation. Further experiments on periosteal distraction osteogenesis (Schmidt et al 2002) and the effects of tensile strain on periosteal cells (Kanno et al 2005) would help to quantify and explain the bone modeling that occurs in response to periosteal tension.…”

“…Quasi-static, pulsatile, and intermittent surface pressures have been reported in the literature to lead to bone resorption or a decrease in bone formation in many different skeletal locations, including the vertebrae, ribs, phalanges, maxilla, middle ear, tibia, and cranial vault (Feik et al 1987;Gooding et al 1969;Hall and Watt 1986;King et al 1991;Orisek and Chole 1987;Sato et al 1998;Skripitz and Aspenberg 2000;von Böhl et al 2004;Voyvodic et al 1992;Wang and Hodges 1994). In contrast to the osteoclastic or reduced osteoblastic response to surface pressures, quasi-static tensile strains applied in a direction perpendicular to a bone surface due to bending of rat vertebrae, bending of early bone rudiments, brain growth, orthodontic force, periosteal distraction, and tumor growth have been shown to lead to bone apposition (Feik et al 1987;Amprino 1985;Henderson et al 2004;King et al 1991;von Böhl et al 2004;Schmidt et al 2002;Yochum and Rowe 2005). Together, these studies suggest that, in addition to the intracortical stresses and strains arising due to axial, bending, and torsional loads applied Muscles and other surrounding soft tissues are indicated by the grey zones.…”

Image Analysis of Lateral Alveolar Ridge Augmentation using Periosteal Distraction Osteogenesis

“…Osteogenesis can be achieved by periosteal distraction. This method obtains new bone tissue by using periosteal mesenchymal stem cells that are capable of differentiating into osteoblasts 1,10,11) . Distraction osteogenesis is successful because under appropriate levels of stimulation periosteal mesenchymal stem cells differentiate into osteoblasts and produce early subperiosteal callus within the osteotomized gap [12][13][14] .…”

“…Kostopoulos et al 1) stated that tenting the periosteum on the lateral ramus after placement of a subperiosteal capsule is sufficient to produce significant amounts of subperiosteal bone and tension on the periosteum, which can lead to the production of subperiosteal bone. Schmidt et al 11) performed bone augmentation by periosteal distraction with a custom-made periosteal distraction device. They stated that controlled distraction of the periosteum is technically feasible, and generation of bone in situ through periosteal distraction without corticotomy is theoretically ideal for producing small amounts of bone in the oral and maxillofacial region.…”

“…In contrast, slight bone resorption was observed in the control group. Schmidt et al 11) who studied the rabbit mandibular branch, reported that their bone augmentation averaged 8) compared the bone increase histologically over 10 days in the case of performing extension all at once or gradually at increments of 5 mm of extension by periosteal distraction, which allowed early bone formation. We also reported dense trabecular bone formation.…”